| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-05-08 |
| タイトル |
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|
タイトル |
Beneficial influence of low-density lipoprotein cholesterol on the endothelium in relation to endothelial repair |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Atherosclerosis |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
CD34-positive cell |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
CAVI |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Endothelial repair |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
LDL |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
LDL paradox |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Shimizu, Yuji
Kawashiri, Shin-Ya
Yamanashi, Hirotomo
Nakamichi, Seiko
Hayashida, Naomi
Nagata, Yasuhiro
Maeda, Takahiro
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Background: Low-density lipoprotein cholesterol (LDLc) is regarded as a risk factor for endothelial dysfunction. However, LDLc stimulates the proliferation of hematopoietic stem cells (CD34-positive cells), which contribute to endothelial repair. Therefore, LDLc may have a beneficial influence on the endothelium of individuals with lower endothelial repair activity. Methods: This cross-sectional study included 245 men aged 60–69 years. Endothelial repair activity was categorized by the circulating levels of CD34-positive cells based on median values. The status of endothelium was evaluated using the cardio-ankle vascular index (CAVI). Results: Among individuals with low levels of circulating CD34-positive cells, LDL-c levels were significantly inversely correlated with CAVI and positively correlated with circulating CD34-positive cells. No significant correlations were observed among the participants with high levels of circulating CD34-positive cells. Among low levels of CD34-positive cells, the adjusted standardized parameter (β) and p value were −0.24 (p = 0.021) for CAVI and 0.41 (p < 0.001) for CD34-positive cells, whereas among high levels of CD34-positive cells, the corresponding values were 0.03 (p = 0.738) and −0.09 (p = 0.355). Conclusion: LDLc has a beneficial influence on endothelial health among individuals with low endothelial repair activity, possibly by stimulating the proliferation of hematopoietic stem cells. |
|
言語 |
en |
| 書誌情報 |
en : Environmental Health and Preventive Medicine
巻 30,
p. art. no. 24,
発行日 2025-04-05
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| 出版者 |
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|
出版者 |
The Japanese Society for Hygiene |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1342-078X |
| DOI |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1265/ehpm.24-00332 |
| 権利 |
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|
権利情報 |
© The Author(s) 2025. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
|
言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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内容記述タイプ |
Other |
|
内容記述 |
Environmental Health and Preventive Medicine, 30, art. no. 24; 2025 |
|
言語 |
en |
EHPM30_24.pdf (882 KB)
