| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-05-15 |
| タイトル |
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タイトル |
Cross‐Organ Proteome Analysis Reveals Changes in Protein Expression Related With Glucose and Amino Acid Metabolism in Muscles and Hearts of Torpid Mice |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
cardiac metabolism |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
glucose metabolism |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
skeletal muscle metabolism |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
transcription regulation |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Miyamoto, Hirotaka
Ito, Shingo
Ogata, Seiryo
Shimojima, Ryoko
Sato, Keiko
Kadowaki, Tomoko
Tokunaga, Ayako
Sato, Kayoko
Kodama, Yukinobu
Nakashima, Mihoko N.
Nishida, Koyo
Nakashima, Mikiro
Ohtsuki, Sumio
Ohyama, Kaname
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Mammals undergoing hibernation or torpor can reduce their metabolic rate. However, the mechanisms of hypometabolism in hibernating animals remain unclear. Analysis of hibernation mechanisms, taking into account commonalities and differences among organs, is essential for a comprehensive understanding of this reduction in physiological activity. Therefore, we investigated and compared changes in protein expression in the hearts and skeletal muscles of torpid mice using quantitative proteomics. Most of the 108 proteins commonly decreased in both tissues were related to translation, and the decrease in protein expression under torpid conditions was greater in muscle than in the heart. Furthermore, glycolysis related to proteins and pyruvate dehydrogenase expression was significantly decreased only in skeletal muscle. In contrast, only three proteins had significantly increased expression in the heart and muscles, with pyruvate dehydrogenase kinase 4 being the most increased. These results suggested that glucose consumption was reduced under torpid conditions. Our results suggest that the heart and muscles respond to low nutritional levels during torpor by reducing glucose and amino acid consumption to preserve energy. Moreover, this adaptation occurs more strongly in skeletal muscle than in the heart. |
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言語 |
en |
| 書誌情報 |
en : Cell Biochemistry and Function
巻 43,
号 4,
p. art. no. e70076,
発行日 2025-04-20
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| 出版者 |
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出版者 |
John Wiley & Sons Ltd |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0263-6484 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1002/cbf.70076 |
| 権利 |
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権利情報 |
© 2025 John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Cell biochemistry and function, 43(4), art. no. e70076, which has been published in final form at https://doi.org/10.1002/cbf.70076. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 引用 |
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内容記述タイプ |
Other |
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内容記述 |
Cell biochemistry and function, 43(4), art. no. e70076; 2025 |
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言語 |
en |
CBF43_e70076.pdf (974 KB)
