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Mode of antiviral action of the galactose-specific lectin, AJLec, on the Junin virus propagation
http://hdl.handle.net/10069/0002002390
http://hdl.handle.net/10069/00020023900c94cab5-e6a0-4839-b203-29df0c7128b6
| 名前 / ファイル | ライセンス | アクション |
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AR240_106189.pdf (628 KB)
Download is available from 2026/5/24.
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
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| 公開日 | 2025-06-05 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Mode of antiviral action of the galactose-specific lectin, AJLec, on the Junin virus propagation | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Junin virus | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Arenavirus | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Lectin | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Antiviral | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 著者 |
Urata, Shuzo
× Urata, Shuzo
× Lee, Meion
× Tsuruta, Tomoko
× Igarashi, Reo
× Takeda, Kohsuke
× Unno, Hideaki
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| 抄録 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Junin virus (JUNV), a member of Arenaviridae, is the causative agent of Argentine hemorrhagic fever (AHF). Available AHF treatments are limited; therefore, development of effective and safe treatments is required. Thus, in this study, novel lectins were examined for anti-JUNV activity. To evaluate JUNV propagation, a recombinant Junin virus vaccine strain (r3Candid #1/ZsGreen) containing the ZsGreen gene as a marker in the viral genome was used. The anti-JUNV effects of four types of marine organism-derived lectins collected in Japan, including the Nagasaki Prefecture, were examined. AJLec, which was extracted from the Sea Anemone Anthopleura japonica, reduced the number of infected cells and viral production. Infection and infection-surrogate assays revealed that incubation of AJLec with viruses and cells before infection, and maintaining it during infection, was required to exhibit full antiviral activity. Moreover, the anti-JUNV activity of AJLec was suppressed by the addition of lactose; hence, the anti-JUNV activity of AJLec was a result of its galactose recognition. This indicates the importance of galactose on the surface of the Junin virion and the cell membrane for entry into cells. Overall, these results provide new insights into the anti-JUNV activity of AJLec. Particularly, the potential of lectins as new antiviral agents that inhibit pathogenic arenavirus replication and propagation is promising. | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 書誌情報 |
en : Antiviral Research 巻 240, p. art. no. 106189, 発行日 2025-05-24 |
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| 出版者 | ||||||||||||||||||
| 出版者 | Elsevier B.V. | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| ISSN | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 01663542 | |||||||||||||||||
| DOI | ||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | 10.1016/j.antiviral.2025.106189 | |||||||||||||||||
| 権利 | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 権利情報 | © 2025 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/. | |||||||||||||||||
| 著者版フラグ | ||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||
| 引用 | ||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | Antiviral Research, 240, art. no. 106189; 2025 | |||||||||||||||||
| 言語 | en | |||||||||||||||||
