| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-06-10 |
| タイトル |
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タイトル |
Clinical characteristics and outcomes of paediatric acute lymphoblastic leukaemia in a tertiary hospital in Tanzania: a single-centre observational study |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Acute lymphoblastic leukaemia |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Sub-Saharan Africa |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Paediatric |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Global health |
| キーワード |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
LMICs |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Shimizu, Koki
Luhulla, Koga
Msoffe, Magreth
Chambega, Chambega
Mahawi, Salama
Ewald, Primus
Sandi, Godlove
Msirikale, Irene
Philbert, Ruchius
Kabona, Regina
Chirande, Lulu
Nakiddu, Nana Jacqueline
Scanlan, Patricia
Smith, Chris
Miyazaki, Yasushi
Maringe, Camille
Rachet, Bernard
Mwamtemi, Hadija
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background: A wide inequality exists between high- and low-income countries in the outcome of paediatric acute lymphoblastic leukaemia (ALL). At a tertiary-level hospital in Tanzania, multidimensional approaches have been taken to improve cancer care for children. This study aimed to update the outcomes of paediatric ALL at Muhimbili National Hospital (MNH), Tanzania from 2016 to 2020. Methods: We performed a retrospective chart review of children who were treated with modified UKALL2003 protocol at MNH from January 1, 2016 to December 31, 2020. We used the Cox proportional hazards model to estimate the effect of each prognostic factor on event-free survival (EFS). Results: We identified 202 patients who had confirmatory diagnoses of ALL and initiated treatment at MNH. Fifty-two patients (26%, 52/202) died (n = 47) or abandoned treatment (n = 5) before the end of remission induction. The main causes of death during this period were infections and bleeding complications. The median EFS was 9 months and 2-year EFS was 36%. Oedema, non-early rapid responder, and non-remission were associated with short EFS in the multivariable analysis. Conclusions: The number of new paediatric ALL admissions at MNH has doubled in the past decade. The prevention of early deaths is critical to improve the long-term survival of paediatric ALL in Tanzania. |
|
言語 |
en |
| 書誌情報 |
en : Tropical Medicine and Health
巻 53,
号 1,
p. art. no. 76,
発行日 2025-05-27
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| 出版者 |
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出版者 |
BioMed Central Ltd |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1349-4147 |
| DOI |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1186/s41182-025-00760-2 |
| 権利 |
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権利情報 |
© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
|
言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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内容記述タイプ |
Other |
|
内容記述 |
Tropical Medicine and Health, 53(1), art. no. 76; 2025 |
|
言語 |
en |
TMH53_76.pdf (2.2 MB)
