| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-06-10 |
| タイトル |
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|
タイトル |
Associations between pathological features and radioactive iodine-refractory recurrent papillary thyroid carcinoma: with mutation analysis using recurrent samples |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Radioactive iodine refractory |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Recurrent papillary thyroid carcinoma |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
BRAFV600E |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
TERT promoter |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Tall cell |
| キーワード |
|
|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
Mitosis |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Nguyen, Thi Nhung
Mussazhanova, Zhanna
Kurohama, Hirokazu
Hoang, Van Dong
Le, Ngoc Ha
Ngo, Thi Minh Hanh
Nguyen, Van Phu Thang
Matsuda, Katsuya
Matsuoka, Yuki
Tratsiakova, Katsiaryna
Nguyen, Thi Ngoc Anh
Sailaubekova, Yerkezhan
Nguyen, Thi Phuong
Le, Minh Son
Nakashima, Masahiro
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background: Although papillary thyroid carcinomas (PTC) are usually indolent in nature and clinically controllable, two-thirds of metastatic diseases become radioactive iodine-refractory (RAI-R). This study aimed to determine the role of pathological features, BRAFV600E, TERT promoter (TERT-p), and their combinations on Vietnamese patients with RAI-R recurrent PTC. Methods: This cross-sectional study included 174 cases of locoregional recurrent PTC, including 135 and 39 RAI-R and RAI-avid (RAI-A) cases, respectively. Logistic regression analyses were used to evaluate the associations between pathological features, mutations, and RAI-R with tissues from recurrent lesions. Results: Loss of polarity/loss of cell cohesiveness (LOP/LCC) component was exclusively observed in recurrent cancers in the RAI-R group. RAI-R was associated with BRAFV600E mutation, TERT-p mutation, BRAFV600E/TERT-p single mutant (Smut), BRAFV600E/TERT-p double mutant (Dmut), tall cell component, and mitosis ≥ 2/2 mm2 in the unadjusted logistic regression analysis. Multivariable logistic regression analysis revealed that BRAFV600E mutation and Dmut were independent predictors of RAI-R. The presence of Dmut (odds ratio [OR] = 6.64) was more significantly associated with RAI-R compared with that of Smut (OR = 2.75). There was a marginal association between tall cell > 5%, mitosis count ≥ 2/2 mm2 and RAI-R. The combination of BRAFV600E/tall cell components was the strongest predictor of RAI-R. Conclusions: RAI-R PTC cases were independently associated with BRAFV600E, Dmut. The association between Dmut and RAI-R PTC was stronger than that between Smut and RAI-R PTC. Future studies should focus on elucidating the role of mitotic count and LOP/LCC in RAI-R PTC. |
|
言語 |
en |
| 書誌情報 |
en : BMC Endocrine Disorders
巻 25,
号 1,
p. art. no. 134,
発行日 2025-05-20
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| 出版者 |
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出版者 |
BioMed Central Ltd |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1472-6823 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1186/s12902-025-01954-9 |
| 権利 |
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権利情報 |
© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creati vecommons.org/licenses/by-nc-nd/4.0/. |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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内容記述タイプ |
Other |
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内容記述 |
BMC Endocrine Disorders, 25(1), art. no. 134; 2025 |
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言語 |
en |
BMCED25_134.pdf (1.9 MB)
