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アイテム
Association between gross features and coexistence of BRAFV600E and TERT promoter mutations in papillary thyroid carcinomas: a combined analysis incorporating clinicopathologic features
http://hdl.handle.net/10069/0002002410
http://hdl.handle.net/10069/0002002410ec2eb34f-b358-4ad0-b84f-a714a55aa123
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KISYK49_Nguyen.pdf (1.1 MB)
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| アイテムタイプ | 学位論文 / Thesis or Dissertation(1) | |||||||
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| 公開日 | 2025-06-12 | |||||||
| タイトル | ||||||||
| タイトル | Association between gross features and coexistence of BRAFV600E and TERT promoter mutations in papillary thyroid carcinomas: a combined analysis incorporating clinicopathologic features | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 著者 |
NGUYEN, THI NGOC ANH
× NGUYEN, THI NGOC ANH
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Background: The coexistence of v-Raf murine sarcoma viral oncogene homolog B1 (BRAFV600E) and telomere reverse transcriptase promoter (TERT-p) mutations is considerably associated with aggressiveness and poor prognosis in papillary thyroid carcinoma (PTC). However, the association between gross findings and genetic alterations in PTC remains unknown. We aimed to investigate the association between clinicopathologic features, including macroscopic features, and the coexistent BRAFV600E and TERT-p mutations in patients with PTC. Methods: We retrospectively analyzed 375 cases of PTC surgically resected between January 2018 and October 2023 at a single institution, based on the presence of BRAFV600E and TERT-p double mutation. Clinicopathologic features, including gross features on the cut surface of tumors, were evaluated. Subsequently, the association between clinicopathologic features and mutation status was statistically examined. Cox proportional hazard models were used to analyze the impact of molecular pathological features on disease-free survival (DFS). Results: The BRAFV600E and TERT-p double mutation was identified in 78 (20.8%) patients among the PTC cases and was significantly correlated with shorter DFS. Multivariable analysis revealed that factors such as relatively older age (≥55 years) (odds ratio [OR] = 12.083, 95% confidence interval [CI] 4.498–32.456), larger tumor size (>2.0 cm) (OR = 2.722, CI 1.104–6.712), lobulated tumor margins (OR = 16.114, CI 3.155–82.296), papillary excrescences on the cut surface (OR = 17.573, CI 3.462–89.201), solid-cut surface (OR = 4.012, CI 1.084–14.849), minimal extrathyroidal extension (ETE) (OR = 4.156, CI 1.209–14.282), gross ETE (OR = 6.517, CI 1.734–24.490), and Ki-67 labeling index (LI) (≥5%, OR = 12.145, CI 4.354–33.877) were significantly associated with the double mutation. Conclusions: The BRAFV600E and TERT-p double mutation in PTC was significantly associated with relatively old age, larger tumor size, lobulated configuration in tumor margin, papillary excrescences on the cut surface, solid-cut surface, ETE, and high Ki-67 LI. These features are suggestive of the presence of the double mutation and should be analyzed at the molecular level in patients with PTC. | |||||||
| 言語 | en | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 長崎大学学位論文 学位記番号:共博(医歯薬)甲第49号 学位授与年月日:令和7年3月19日 | |||||||
| 言語 | ja | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Author: Thi Ngoc Anh Nguyen, Van Phu Thang Nguyen, Hirokazu Kurohama, Yuko Akazawa, Katsuya Matsuda, Zhanna Mussazhanova, Yuki Matsuoka, Kenichi Yokota, Shinya Satoh, Hiroyuki Yamashita, Thi Nhung Nguyen, Yerkerzhan Sailaubekova, and Masahiro Nakashima | |||||||
| 言語 | en | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Citation: Thyroid, 34(12), pp.1476-1485; 2024 | |||||||
| 言語 | en | |||||||
| 書誌情報 |
en : Thyroid 巻 34, 号 12, p. 1476-1485, 発行日 2025-03-19 |
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| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 1050-7256 | |||||||
| DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1089/thy.2024.0310 | |||||||
| 権利 | ||||||||
| 権利情報 | Copyright 2024, Mary Ann Liebert, Inc., publishers. Final publication is available from Mary Ann Liebert, Inc., publishers http://dx.doi.org/10.1089/thy.2024.0310. | |||||||
| 言語 | en | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| その他のタイトル | ||||||||
| その他のタイトル | 甲状腺乳頭癌の肉眼像とBRAFV600EおよびTERT promoter変異との関連：その他臨床病理学的特徴を含めた解析 | |||||||
| 言語 | ja | |||||||
| 出版者 | ||||||||
| 出版者 | Mary Ann Liebert, Inc | |||||||
| 言語 | en | |||||||
| 関係URI | ||||||||
| 識別子タイプ | HDL | |||||||
| 関連識別子 | http://hdl.handle.net/10069/0002002348 | |||||||
| 学位名 | ||||||||
| 学位名 | 博士(医学) | |||||||
| 言語 | ja | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 17301 | |||||||
| 学位授与機関名 | Nagasaki University (長崎大学) | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2025-03-19 | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲共医歯薬第49号 | |||||||
| 学位の種類 | ||||||||
| 言語 | ja | |||||||
| 値 | 課程博士 | |||||||
| 引用 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Nagasaki University (長崎大学), 博士(医学) (2025-03-19) | |||||||
