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  1. 110 医歯薬学総合研究科 = Graduate School of Biomedical Sciences
  2. 110 学位論文 = dissertation
  3. 110 学位論文 = dissertation

Overdiagnosis of atypical lipomatous tumors/well-differentiated liposarcomas by morphological diagnosis using only HE stained specimens: a case-control study with MDM2/CDK4 immunostaining and MDM2/CDK4 fluorescence in situ hybridization

http://hdl.handle.net/10069/0002002420
http://hdl.handle.net/10069/0002002420
0beea212-ca2f-4fcc-b8b0-636a9a897ee4
名前 / ファイル ライセンス アクション
ISYK1665_Nomura.pdf ISYK1665_Nomura.pdf (959 KB)
アイテムタイプ 学位論文 / Thesis or Dissertation(1)
公開日 2025-06-12
タイトル
タイトル Overdiagnosis of atypical lipomatous tumors/well-differentiated liposarcomas by morphological diagnosis using only HE stained specimens: a case-control study with MDM2/CDK4 immunostaining and MDM2/CDK4 fluorescence in situ hybridization
言語 en
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 Atypical lipomatous tumor
キーワード
言語 en
主題Scheme Other
主題 Lipoma
キーワード
言語 en
主題Scheme Other
主題 FISH
キーワード
言語 en
主題Scheme Other
主題 Immunohistochemistry
キーワード
言語 en
主題Scheme Other
主題 MDM2
キーワード
言語 en
主題Scheme Other
主題 CDK4
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
著者 野村, 賢太郎

× 野村, 賢太郎

ja 野村, 賢太郎
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著者別名
姓名 Nomura, Kentaro
言語 en
抄録
内容記述タイプ Abstract
内容記述 Background: Lipomatous tumors represent the most common type of soft tissue neoplasms. Mouse double minute 2 homolog (MDM2)/cyclin-dependent kinase 4 (CDK4) immunostaining is considered effective in differentiating between benign lipomas and intermediate malignant atypical lipomatous tumors/well-differentiated liposarcomas (ALT/WDLPSs). However, these tumors have traditionally been diagnosed histopathologically using hematoxylin and eosin-stained specimens, which is referred to here as morphological diagnosis. In this study, the accuracy of morphological diagnoses that had been made before MDM2/CDK4 immunostaining became available for distinguishing between lipoma and ALT/WDLPS was examined. Methods: The study participants were 109 patients with a morphological diagnosis of lipoma (68 patients) or ALT/WDLPS (41 patients) who had undergone surgical resection of the tumor in our hospital between 2009 and 2012. Tissue samples from all patients were used for MDM2/CDK4 immunostaining and the confirmation of MDM2/CDK4 amplification by fluorescence in situ hybridization (FISH). Results: Of the 41 patients with a morphological diagnosis of ALT/WDLPS, only 17 were positive for MDM2 FISH. In addition, one of the 68 patients with a morphological diagnosis of lipoma showed MDM2 amplification by FISH. When the definitive diagnosis of ALT/WDLPS was made by the positive results of MDM2 FISH, the sensitivity and specificity of morphological diagnosis were 41.5% and 98.5%, respectively. The sensitivity of MDM2 and CDK4 immunostaining was 55.6% and 40.0%, respectively, and their specificity was 87.0% and 84.6%, respectively. This indicates that the diagnostic accuracy of these immunostaining assays was not particularly high. The clinical features suggesting ALT/WDLPS were: patient age (older), maximum tumor diameter (large, cut-off value of 125 mm), tumor location (lower limb), and tumor depth (deep-seated). Conclusions: Morphological diagnosis alone can accurately diagnose lipomas. However, it has a propensity to overdiagnose ALT/WDLPS. Thus, MDM2 FISH should be used more proactively, not only for lesions with obvious morphological abnormalities, but also for lipomatous tumors that are clinically suggestive of ALT/WDLPS.
言語 en
内容記述
内容記述タイプ Other
内容記述 長崎大学学位論文 学位記番号:博(医歯薬)甲第1665号 学位授与年月日:令和7年3月5日
言語 ja
内容記述
内容記述タイプ Other
内容記述 Author: Kentaro Nomura, Masato Tomita, Kishio Kuroda, Masakazu Souda, Ko Chiba, Akihiko Yonekura and Makoto Osaki
言語 en
内容記述
内容記述タイプ Other
内容記述 Citation: BMC Cancer, 24, art. no. 1437; 2024
言語 en
書誌情報 en : BMC Cancer

巻 24, p. art. no. 1437, 発行日 2025-03-05
ISSN
収録物識別子タイプ ISSN
収録物識別子 1471-2407
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 10.1186/s12885-024-13215-4
権利
権利情報 This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
言語 en
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
その他のタイトル
その他のタイトル 形態学的診断は脂肪腫では有効であるが異型脂肪腫様腫瘍/高分化型脂肪肉腫では過剰診断が多い：MDM2とCDK4の免疫染色とFISHを用いたcase control study
言語 ja
出版者
出版者 BioMed Central Ltd
言語 en
関係URI
識別子タイプ HDL
関連識別子 http://hdl.handle.net/10069/0002002301
学位名
学位名 博士(医学)
言語 ja
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 17301
学位授与機関名 Nagasaki University (長崎大学)
学位授与年月日
学位授与年月日 2025-03-05
学位授与番号
学位授与番号 甲医歯薬第1665号
学位の種類
言語 ja
値 課程博士
引用
内容記述タイプ Other
内容記述 Nagasaki University (長崎大学), 博士(医学) (2025-03-05)
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