| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-07-08 |
| タイトル |
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タイトル |
Dengue Infections Among Household Contacts of Symptomatic Index Cases: Implications for Community-Based Intervention Studies |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
dengue |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
infection |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
household contacts |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
community |
| キーワード |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Vietnam |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Koehne, Erik
Van, Wesenbeeck Liesbeth
Hibberd, Martin L.
Buelens, Annemie
Toizumi, Michiko
Clerck, Kim De
Vijgen, Leen
Lagatie, Ole
Masdin, Lucy
Nguyen, Hien Anh Thi
Le, Hoang Huy
Dang, Duc Anh
Huynh, Mai Kim
Le, Lien Thuy
Nguyên, Trieu Bao
Hue, Stephane
Do, Hung Thai
Herrera-Taracena, Guillermo
Rasschaert, Freya
Yoshida, Lay-Myint
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background: Dengue is a global health concern, with half of the world’s population at risk and no antiviral treatment available. This Phase 0 study investigated dengue infections among household contacts (HHCs) of dengue index cases (ICs) and assessed the feasibility of conducting a Phase 2 trial for a novel antiviral. Methods: Participants were enrolled in Nha Trang, Vietnam, from April 2022 to February 2023. Dengue ICs were identified within 72 h of fever onset, and their healthy adult HHCs enrolled within 48 h. Blood samples and questionnaires were collected bi-weekly for four weeks, with a follow-up visit on day 40. DENV RT-qPCR, NS1, and anti-DENV IgM/IgG ELISAs were performed. Results: Overall, 130 dengue ICs and 301 HHCs were enrolled, with 91.7% (276/301) completing all follow-up visits. Baseline anti-DENV IgG showed prior dengue infections in 262/301 HHCs (87.0%). Fifty HHCs were excluded from the HHC infection analysis based on evidence of a DENV infection (viral load [VL], NS1, IgM, and IgG results) at enrollment. During follow-up, 2.0% of HHCs (5/251) had DENV infections based on virological parameters (DENV RNA and/or NS1 positivity), and anti-DENV IgG/IgM seroconversion was detected in 7.2% (18/251). Conclusions: This study demonstrated the operational feasibility of a dengue IC-HHC design for a Phase 2 trial. |
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言語 |
en |
| 書誌情報 |
en : Viruses
巻 17,
号 6,
p. art. no. 859,
発行日 2025-06-17
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| 出版者 |
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出版者 |
MDPI |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1999-4915 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.3390/v17060859 |
| 権利 |
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権利情報 |
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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内容記述タイプ |
Other |
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内容記述 |
Viruses, 17(6), art. no. 859; 2025 |
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言語 |
en |
V17_859.pdf (2.7 MB)
