| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-07-08 |
| タイトル |
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|
タイトル |
Risk Factors and Long‐Term Prognosis for Coinfection of Nontuberculous Mycobacterial Pulmonary Disease and Chronic Pulmonary Aspergillosis: A Multicentre Observational Study in Japan |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Aspergillus |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
coinfection |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Mycobacterium avium complex |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Mycobacterium infections |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
nontuberculous mycobacteria |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
propensity score |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
pulmonary aspergillosis |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
retrospective studies |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Tanaka, Yasuhiro
Ide, Shotaro
Takazono, Takahiro
Takeda, Kazuaki
Iwanaga, Naoki
Yoshida, Masataka
Hosogaya, Naoki
Tsukamoto, Yusei
Irifune, Satoshi
Suyama, Takayuki
Mihara, Tomo
Kondo, Akira
Kobayashi, Tsutomu
Fukuda, Yuichi
Sasaki, Eisuke
Sawai, Toyomitsu
Higashiyama, Yasuhito
Hashiguchi,Kohji
Hanaka, Minako
Ii, Toshihiko
Fukushima, Kiyoyasu
Komiya, Kosaku
Miyazaki, Taiga
Yatera, Kazuhiro
Izumikawa, Koichi
Furumoto, Akitsugu
Yanagihara, Katsunori
Mukae, Hiroshi
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background: Nontuberculous mycobacterial pulmonary disease (NTM-PD) is a chronic respiratory infection with increasing prevalence and mortality worldwide. Coinfection with chronic pulmonary aspergillosis (CPA) is a significant complication of NTM-PD, often complicating treatment and resulting in poor prognosis. Objective: In this multicentre, retrospective cohort study, we examined the epidemiology, comorbidities, risk factors for CPA coinfection and long-term prognosis of patients with NTM-PD infected with CPA in Japan. Methods: Patients aged ≥ 18 years with newly diagnosed NTM-PD who visited 18 hospitals between 2010 and 2017 in Kyushu, Japan, were included. Medical records were reviewed for patient characteristics, mycobacterial species, laboratory data, radiological features, Aspergillus coinfection and all-cause mortality rates. Risk factors for CPA coinfection were analysed using multiple logistic regression, and survival analysis was performed before and after propensity score matching with risk factors. Results: Among 1304 patients with NTM-PD, 45 (3.5%) were diagnosed with CPA, including 42 with chronic progressive pulmonary aspergillosis. The risk factors for CPA coinfection included male sex, chronic obstructive pulmonary disease, oral corticosteroid use and cavity formation. All-cause mortality was significantly higher in patients with NTM-PD with CPA than in those without CPA (log-rank test, p < 0.001; crude hazard ratio [HR], 3.98). Survival analysis after propensity score matching suggested CPA was an independent poor prognostic factor (log-rank test, p = 0.036; adjusted HR, 1.59). Conclusion: CPA is an independent poor prognostic factor in patients with NTM-PD. Clinicians must consider CPA when treating patients with NTM-PD, particularly those with high-risk factors, to ensure timely diagnosis and management. |
|
言語 |
en |
| 書誌情報 |
en : Mycoses
巻 68,
号 6,
p. art. no. e70083,
発行日 2025-06-19
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| 出版者 |
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出版者 |
Wiley-VCH GmbH |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0933-7407 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1111/myc.70083 |
| 権利 |
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権利情報 |
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2025 The Author(s). Mycoses published by Wiley-VCH GmbH |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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内容記述タイプ |
Other |
|
内容記述 |
Mycoses, 68(6), art. no. e70083; 2025 |
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言語 |
en |
M68_e70083.pdf (447 KB)
