| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-07-29 |
| タイトル |
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タイトル |
Predicting absorption of compounds from an in vivo liver surface based on molecular weight or in vitro release using a dialysis membrane in combination with lipophilicity |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Yuan, Fei
Torigoe, Ayaka
Mitsudome, Nao
Miyamoto, Hirotaka
Fumoto, Shintaro
Toriba, Akira
Nishida, Koyo
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
A liver surface application (LSA) was developed to reduce the side effects of chemotherapy in liver cancer. The effects of molecular weight (MW) and lipophilicity (log PC) on the absorption of hydrophilic and lipophilic compounds from the rat liver surface were examined. However, how these two factors simultaneously affect compound absorption remains unclear. The combined effects of MW and log PC on the absorption of these compounds in rats and mice were investigated. The compounds were administered to the liver surface using a cylindrical diffusion cell, and in vitro release experiments were conducted using a dialysis membrane to explore the relationship between release and absorption. The results indicate that log (PC/MW0.5) has a significant linear correlation with log Papp, absorption (Papp, apparent permeability coefficient). Similarly, a significant correlation was observed between log (PC × Papp, release) and log Papp, absorption. These two relationships observed in rats were used to predict compound absorption in mice, and the predicted values closely matched the experimental data. This implies that both combinations of MW and in vitro release with log PC can explain compound absorption from the liver surface. This study provided important information for understanding the absorption characteristics of LSA. |
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言語 |
en |
| 書誌情報 |
en : RSC Pharmaceutics
巻 2,
号 4,
p. 761-771,
発行日 2025-05-01
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| 出版者 |
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出版者 |
Royal Society of Chemistry |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2976-8713 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1039/D5PM00054H |
| 権利 |
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権利情報 |
© 2025 The Author(s). Published by the Royal Society of Chemistry This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence. |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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内容記述タイプ |
Other |
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内容記述 |
RSC Pharmaceutics, 2(4), pp.761-771; 2025 |
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言語 |
en |
RSCP2_761.pdf (856 KB)
