| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-08-08 |
| タイトル |
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タイトル |
Genomic analysis and molecular profiling of dengue viruses in Sabah, Malaysia during 2019-2020 |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Dengue virus |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
Complete genome |
| キーワード |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Phylogenetic tree |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Sabah |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Ngwe, Tun Mya Myat
John, Jecelyn Leaslie
Nabeshima, Takeshi
Manah, Abdul Marsudi
Takamatsu, Yuki
Urano, Takeshi
Morita, Kouichi
Ahmed, Kamruddin
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Objectives: Limited information is available on the distribution of dengue virus (DENV) serotypes and genotypes in Borneo, particularly, in Sabah, because most studies have focused on Peninsular Malaysia. This study aimed to investigate the serologic and molecular epidemiologic characteristics of DENV in patients from Sabah. Methods: Serum samples were collected from febrile patients in Kota Kinabalu and Lahad Datu between 2019 and 2020 at the Kota Kinabalu Public Health Laboratory. We performed virus isolation, serological testing, viremia quantification, and complete genome sequencing. Results: Of 188 serum samples, 89 tested positive for DENV by quantitative reverse transcription-polymerase chain reaction: 20 DENV-1, 46 DENV-2, 20 DENV-3, and 1 DENV-4. A total of 38 viruses were successfully isolated. The isolates belonged to DENV-1 (genotypes I and IV), DENV-2 (cosmopolitan genotype) and DENV-3 (genotypes I and III). The phylogenetic analysis revealed close relationships with strains from Malaysia, Indonesia, and the Philippines. DENV-2 was the predominant serotype, whereas the highest viremia levels were observed in patients infected with DENV-3. Conclusions: To the best of our knowledge, this study provides the first detailed phylogenetic and complete genome analysis of DENV in Sabah. Continued molecular surveillance is essential to enhance our understanding of dengue transmission and support effective control strategies. |
|
言語 |
en |
| 書誌情報 |
en : IJID Regions
巻 16,
p. art. no. 100712,
発行日 2025-08-01
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| 出版者 |
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出版者 |
Elsevier Ltd |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
27727076 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.ijregi.2025.100712 |
| 権利 |
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権利情報 |
© 2025 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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内容記述タイプ |
Other |
|
内容記述 |
IJID Regions, 16, art. no. 100712; 2025 |
|
言語 |
en |
IJIDR16_100712.pdf (1.3 MB)
