| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-08-08 |
| タイトル |
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|
タイトル |
Emergence of Dengue Virus Serotypes 1 and 3 in Mahottari and Adjacent Areas of Southern Nepal |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
dengue |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
DENV serotype |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
viral load |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
epidemiology |
| キーワード |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
outbreak |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
surveillance |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Nepal |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Shrestha, Sabin
Rimal, Sandesh
Kharbuja, Anjana
Ray, Manoj Kumar
Shrestha, Susmita
Dulal, Anjali
Subedi, Suprabha
Khadka, Ashma
Adhikari, Nabaraj
Dhimal, Meghnath
Pandey, Basu Dev
Urano, Takeshi
Morita, Kouichi
Ngwe, Tun Mya Myat
Dumre, Shyam Prakash
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Dengue has been a serious public health concern in Nepal since the past few years, with concurrent big outbreaks occurring in 2022–2024. This cross-sectional study was conducted among febrile patients visiting hospitals in Mahottari district in southern Nepal. A total of 2141 dengue-suspected patients were investigated by routine laboratory assays and serological and molecular techniques, including real-time quantitative polymerase chain reaction (RT-qPCR). Among them, 455 (21.3%) were confirmed as dengue cases. The majority of dengue cases (435, 95.6%) had a primary dengue infection. The total bilirubin level was significantly higher in secondary dengue infection than in primary (p = 0.032). The major dengue virus (DENV) serotypes responsible for this outbreak were DENV-1 (45.5%) and DENV-2 (40.9%), while 13.6% patients had DENV-3 infection. DENV-3 infection showed a significantly higher viral load (median: 7.71 Log10 copies/mL; range: 6.48–7.94) compared to DENV-1 (6.72 Log10 copies/mL; 5.49–7.17) and DENV-2 (4.76 Log10 copies/mL; 2.32–6.96). Adult patients exhibited a significantly higher viral load than children (p = 0.035). NS1- and IgM-positive as well as admitted patients had a higher viral load (p < 0.05). Co-circulation of multiple serotypes (DENV-1, -2, -3) was confirmed with the first introduction of DENV-1 and DENV-3 in Mahottari and surrounding areas in the 2023 outbreak. Identification of the circulating DENV serotypes is crucial to understanding the epidemiological trend and dynamics of population immunity. These findings underscore the need of nation-wide integrated surveillance, including genomic data generation, in Nepal for disease control, prevention, and potential vaccine implication. |
|
言語 |
en |
| 書誌情報 |
en : Pathogens
巻 14,
号 7,
p. art. no. 639,
発行日 2025-06-26
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| 出版者 |
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出版者 |
MDPI |
|
言語 |
en |
| ISSN |
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|
収録物識別子タイプ |
EISSN |
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収録物識別子 |
2076-0817 |
| DOI |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.3390/pathogens14070639 |
| 権利 |
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|
権利情報 |
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
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言語 |
en |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Pathogens, 14(7), art. no. 639; 2025 |
|
言語 |
en |
P14_639.pdf (4.7 MB)
