| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-08-19 |
| タイトル |
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|
タイトル |
Elevated plasma level of PAI-1 is associated with severe COVID-19 |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
COVID-19 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
PAI-1 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Biomarker |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Prognostic factor |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Fukahori, Susumu
Kawazoe, Yurika
Han, Jung Yeon
Kolliputi, Narasaiah
Lezama, Kaitlyn
Kumar, Rajesh
Mukae, Hiroshi
Lockey, Richard F.
Vera, Iset Medina
Kim, Kami
Cho, Seong H.
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Evidence indicates endothelial dysfunction in severe coronavirus disease (COVID-19). Plasminogen activator inhibitor-1 (PAI-1) is a marker of endothelial injury and could be a prognostic marker for COVID-19-related hospitalization and outcomes. The association between PAI-1 levels and the severity of COVID-19-related outcomes was investigated in this study. This single-center retrospective chart review included 113 hospitalized adults from 6.29.2020 to 8.1.2021 with confirmed COVID-19. Plasma PAI-1 levels were measured by ELISA. The primary endpoint was the difference in PAI-1 levels between severe and non-severe COVID-19 groups. Severe COVID-19 was defined as the need for ventilator assistance and/or death. The mean age was 60.78 (22 to 103, SD ± 16.93), and 52 were female and 63 male. There was a significant positive correlation between age and PAI-1 levels. PAI-1 levels were significantly higher in patients with hyperlipidemia. PAI-1 levels in patients requiring ventilator assistance and who died versus those who did not are significantly higher. High plasma PAI-1 levels are associated with severe COVID-19, defined as requiring ventilator use and/or death. Thus, PAI-1 may be a biological marker for severe COVID-19. |
|
言語 |
en |
| 書誌情報 |
en : Scientific Reports
巻 15,
号 1,
p. art. no. 28380,
発行日 2025-08-04
|
| 出版者 |
|
|
出版者 |
Springer Nature |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
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収録物識別子 |
2045-2322 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1038/s41598-025-06517-5 |
| 権利 |
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|
権利情報 |
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
|
言語 |
en |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Scientific Reports, 15(1), art. no. 28380; 2025 |
|
言語 |
en |
SR15_28380.pdf (1.4 MB)
