| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-08-19 |
| タイトル |
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|
タイトル |
Multicentre retrospective observational study for development and validation of MAC prognostic score model |
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言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
MAC prognostic score |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Mycobacterium avium–intracellulare complex |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Prediction model |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Retrospective study |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Takeda, Kazuaki
Takazono, Takahiro
Ide, Shotaro
Yoshida, Masataka
Iwanaga, Naoki
Hosogaya, Naoki
Tsukamoto, Yusei
Irifune, Satoshi
Suyama, Takayuki
Mihara, Tomo
Kondo, Akira
Kobayashi, Tsutomu
Fukuda, Yuichi
Sasaki, Eisuke
Sawai, Toyomitsu
Higashiyama, Yasuhito
Hashiguchi, Kohji
Hanaka, Minako
Ii, Toshihiko
Fukushima, Kiyoyasu
Komiya, Kosaku
Miyazaki, Taiga
Yatera, Kazuhiro
Izumikawa, Koichi
Furumoto, Akitsugu
Yanagihara, Katsunori
Mukae, Hiroshi
|
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
The global incidence and mortality rates of Mycobacterium avium–intracellulare complex pulmonary disease (MAC-PD) are increasing. We conducted a multicentre retrospective cohort study across 18 hospitals to develop a scoring system for predicting respiratory infection-related mortality in patients with MAC-PD. A total of 1,165 patients newly diagnosed with MAC-PD between 2010 and 2017 were enrolled and randomly allocated to a 4:1 ratio to derivation (n = 932) and validation (n = 233) groups. Among them, 656 patients (56.3%) received MAC-PD treatment within 5 years. During the observation period, all-cause mortality occurred in 183 patients (15.7%), and respiratory infection-related mortality occurred in 67 patients (5.8%). To identify the risk factors for respiratory infection-related mortality, Cox proportional hazards analysis was conducted in the derivation group, which informed the development and validation of the prognostic scoring model. Five independent risk factors were identified: age ≥ 65 years, male sex, interstitial pneumonia, albumin < 3.5 g/dL, and cavitary lesions. A prognostic score was developed by assigning 2 points to albumin < 3.5 g/dL and 1 point to each of the other factors. The score demonstrated good predictive performance, with areas under the receiver operating characteristic curves of 0.86 and 0.81 in the derivation and validation groups, respectively. Patients with scores ≥ 3 had significantly poorer prognoses than those with scores ≤ 2. The strength of this study lies in its multicentre validation and focus on respiratory infection-related mortality, providing a clinically useful risk stratification tool for MAC-PD. |
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言語 |
en |
| 書誌情報 |
en : Scientific Reports
巻 15,
号 1,
p. art. no. 28539,
発行日 2025-08-05
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| 出版者 |
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出版者 |
Springer Nature |
|
言語 |
en |
| ISSN |
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|
収録物識別子タイプ |
EISSN |
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収録物識別子 |
2045-2322 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1038/s41598-025-14348-7 |
| 権利 |
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|
権利情報 |
This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/. © The Author(s) 2025 |
|
言語 |
en |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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内容記述タイプ |
Other |
|
内容記述 |
Scientific Reports, 15(1), art. no. 28539; 2025 |
|
言語 |
en |
SR15_28539.pdf (2 MB)
