| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-09-09 |
| タイトル |
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タイトル |
β-glycyrrhetinic acid-containing dentifrice alleviates dental plaque accumulation and gingival inflammation: a randomized, cross-over, placebo-controlled study |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Glycyrrhetinic acid |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Toothpastes |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
Dentifrices |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
Dental plaque |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Gingivitis |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
Clinical trial |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Cross-Over studies |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Yamashita, Yasunori
Sato, Kayo
Okumura, Aya
Eshita, Yoshiyuki
Elazegui, Ralph Jacob Manaig
Yoshimura, Atsutoshi
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background: Plaque control is essential for the prevention of dental caries and periodontal diseases. β-glycyrrhetinic acid (BGA) is an anti-inflammatory compound that has also been shown to be antibacterial. This study aimed to determine the effect of a dentifrice containing BGA on supragingival dental plaque accumulation. Methods: Twenty-five patients who visited the Nagasaki University Hospital for periodontal maintenance from October 2020 to April 2022 were included in this study. It was a cross-over double-blind study, with BGA-containing and placebo toothpaste used for 1 week each. The use of toothpaste was randomly assigned using the block size 2 substitution block method. The primary endpoint was the area of plaque deposition on the margins after 1 week of toothpaste use for all teeth. The plaque deposition area was assessed using the Turesky–Gilmore–Glickmann Modification of the Quigley-Hein Plaque index (M-QHI) and statistically evaluated with a paired t-test. Results: The plaque deposition area of all participants was analyzed after 1 week of use of BGA-containing and placebo toothpaste. The mean M-QHI after using the BGA-containing toothpaste was 0.63 ± 0.19, which was significantly lower (p < 0.001) than the mean M-QHI after using the placebo toothpaste (0.75 ± 0.21). No significant adverse events were observed in any of the patients. Conclusions: BGA-containing dentifrices may be useful in preventing caries and periodontal disease by inhibiting the accumulation of supragingival plaques. Trial registration: This clinical trial was registered on UMIN-CTR (UMIN000040628, A verification study on plaque formation by using a dentifrice) on June 2, 2020. |
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言語 |
en |
| 書誌情報 |
en : BMC Oral Health
巻 25,
号 1,
p. art. no. 1372,
発行日 2025-08-26
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| 出版者 |
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出版者 |
BioMed Central Ltd |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1472-6831 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1186/s12903-025-06737-1 |
| 権利 |
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権利情報 |
© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creati vecommons.org/licenses/by-nc-nd/4.0/ |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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内容記述タイプ |
Other |
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内容記述 |
BMC Oral Health, 25(1), art. no. 1372; 2025 |
|
言語 |
en |
BMCOH25_1372.pdf (1.3 MB)
