| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-09-09 |
| タイトル |
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|
タイトル |
Impact of weight loss and lifestyle modifications on liver fibrosis in MASLD and MetALD: A cohort study |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
MASLD |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
MetALD |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
weight loss |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
abstinence |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
exercise |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Ichikawa, Tatsuki
Miuma, Satoshi
Yamashima, Mio
Yamamichi, Shinobu
Koike, Makiko
Nakano, Yusuke
Yajima, Hiroyuki
Miyazaki, Osamu
Ikeda, Tomonari
Okamura, Takuma
Komatsu, Naohiro
Yoshino, Miruki
Miyaaki, Hisamitsu
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The present study aimed to investigate the impact of weight loss and abstinence and exercise on liver fibrosis in metabolic dysfunction‑associated steatotic liver disease (MASLD) and metabolic dysfunction‑associated steatotic liver disease and alcoholic‑related liver disease (MetALD). A total of 67 patients with MASLD and 33 patients with MetALD were retrospectively evaluated after six months of follow‑up for weight loss, abstinence and exercise. A decrease in liver fibrosis (decrease in dLSM2B) was defined as a reduction in liver stiffness (LS) by FibroScan and macrophage galactose‑specific lectin‑2 binding protein glycosylation isomer (M2BPGi) over the observation period. The decrease in dLSM2B levels was 35.8 and 39.4% in the MASLD and MetALD groups, respectively. In MASLD, the decreased weight rate (dBW%) was lower for a decrease in dLSM2B than for an increase. However, in MetALD, the dBW% was not significantly different between the groups. In MetALD, patients with complete abstinence and exercise frequency had a higher rate of decrease in dLSM2B. A prediction score of 0, 1 or 2 points was developed to predict the decrease in dLSM2B, with 1 point awarded for a dBW% reduction of ≥3.8 and 1 point for a FIB‑4 reduction of ≥0.201. In patients with MASLD, there was a significant difference in the decrease in dLSM2B by 8.3% for a prediction score of 0, 36% for 1, and 72.2% for 2 points, whereas there was no significant difference in the improvement rate for 0‑2 points. In conclusion, weight loss during MASLD and abstinence and exercise during MetALD were associated with a decrease in dLSM2B. |
|
言語 |
en |
| 書誌情報 |
en : Biomedical Reports
巻 23,
号 4,
p. 1-11,
発行日 2025-07-25
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| 出版者 |
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出版者 |
Spandidos Publications |
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言語 |
en |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
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収録物識別子 |
2049-9434 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.3892/br.2025.2036 |
| 権利 |
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|
権利情報 |
© Ichikawa et al. This is an open access article distributed under the terms of Creative Commons Attribution License. |
|
言語 |
en |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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|
内容記述タイプ |
Other |
|
内容記述 |
Biomedical Reports, 23(4), art. no. 158; 2025 |
|
言語 |
en |
BR23_158.pdf (1.9 MB)
