| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-09-09 |
| タイトル |
|
|
タイトル |
Comprehensive analysis of serum immune complexes identifies chronic graft-versus-host disease-associated antigenic molecules: A study by the Nagasaki transplant group |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Chronic graft-versus-host disease |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Immune complexes |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Antigen |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Alloreactive antibody |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
B cell |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Fujioka, Machiko
Itonaga, Hidehiro
Sawayama, Yasushi
Aibara, Nozomi
Kojima, Azusa
Kirino, Yuko
Watanabe, Haruka
Yamada, Yuichi
Sakamoto, Hikaru
Taguchi, Masataka
Kato, Takeharu
Horai, Makiko
Ohyama, Kaname
Miyazaki, Yasushi
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Chronic graft-versus-host disease (cGVHD) is an alloimmune disease characterized by inflammation, immune dysregulation, and pathogenic fibrosis after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Donor-derived B cells have a significant role of cGVHD development; however, the proteins targeted by B cell-mediated cGVHD remain unclear. To identify cGVHD-associated antigens, we investigated immune complexes (ICs) in the serum of patients who underwent allo-HSCT. Of the 26 patients examined, 17 developed cGVHD, and the 1-year cumulative incidence of cGVHD was 57.7%. A comprehensive analysis of ICs identified 89 distinct IC-associated antigen candidates, including significantly enriched clusters associated with “regulation of secretion by cell”, “regulation of protein kinase activity”, “positive regulation of organelle organization”, and “positive regulation of synaptic transmission”. Regarding overlap between the tissue specificity of proteins and cGVHD-affected organs, ten proteins were identified as organ-specific antigen candidates. In summary, the immune complexome analysis identified antigen candidates in patients with cGVHD, suggesting that the heterogeneity of target proteins might lead to, at least in a part, diverse clinical manifestations of cGVHD. The results of this study provide important insights into immune dysregulation in cGVHD. |
|
言語 |
en |
| 書誌情報 |
en : Human Immunology
巻 86,
号 5,
p. art. no. 111569,
発行日 2025-08-27
|
| 出版者 |
|
|
出版者 |
Elsevier Inc |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
01988859 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.humimm.2025.111569 |
| 権利 |
|
|
権利情報 |
© 2025 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/. |
|
言語 |
en |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Human Immunology, 86(5), art. no. 111569; 2025 |
|
言語 |
en |
HI86_111569.pdf (850 KB)
