| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-09-16 |
| タイトル |
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タイトル |
Daikenchuto improves methotrexate-induced chronic small intestinal mucositis by promoting angiogenesis |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
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言語 |
en |
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主題Scheme |
Other |
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主題 |
chemotherapy |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
methotrexate |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
intestinal mucositis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
daikenchuto |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
angiogenesis |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Li, Peilin
Inoue, Yusuke
Sadatomi, Daichi
Mogami, Sachiko
Miyamoto, Daisuke
Adachi, Toshiyuki
Adachi, Tomohiko
Soyama, Akihiko
Kanetaka, Kengo
Gu, Weili
Eguchi, Susumu
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Aim: Chronic small-intestinal mucositis (CIM) is a severe gastrointestinal complication that has limited treatment options. This study investigated the potential therapeutic effects of Daikenchuto (DKT), a traditional medicine, on mitigating methotrexate (MTX)-induced CIM in rats. Methods: Male Sprague-Dawley rats were assigned to four groups: control, MTX, DKT-MTX, and DKT. CIM was induced by intraperitoneal administration of MTX (10 mg/kg every 6 days), while DKT (2.7% wt/wt) was orally administered via feed. The surviving rats were euthanized on day 60. Rat intestinal epithelial cells (IEC-6) were used to examine DKT’s cytoprotective effects in vitro. Results: DKT treatment improved survival, reduced gastrointestinal symptoms, and alleviated histological damage, including villus atrophy and crypt hyperplasia. DKT restored mucosal integrity by enhancing the expression of tight junction proteins (CLDN-3) and nutrient transporters (B0,+AT, EAAT3), and by reducing oxidative stress and epithelial cell death. Furthermore, DKT promoted mucosal angiogenesis, as evidenced by increased expression of CD34, VEGFR2, and VEGFA in both tissues and cells. qRT-PCR confirmed upregulation of genes associated with angiogenesis, barrier repair, and mucosal regeneration. Conclusion: DKT exerts protective effects against MTX-induced CIM by enhancing angiogenesis, promoting epithelial regeneration, and restoring mucosal barrier function. These findings suggest DKT as a promising adjunctive therapy for managing chronic intestinal toxicity induced by chemotherapy. |
|
言語 |
en |
| 書誌情報 |
en : Frontiers in Pharmacology
巻 16,
p. art. no. 1623726,
発行日 2025-08-21
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| 出版者 |
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出版者 |
Frontiers Media SA |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1663-9812 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.3389/fphar.2025.1623726 |
| 権利 |
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権利情報 |
© 2025 Li, Inoue, Sadatomi, Mogami, Miyamoto, Adachi, Adachi, Soyama, Kanetaka, Gu and Eguchi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
|
言語 |
en |
| 著者版フラグ |
|
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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内容記述タイプ |
Other |
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内容記述 |
Frontiers in Pharmacology, 16, art. no. 1623726; 2025 |
|
言語 |
en |
FP16_1623726.pdf (6.2 MB)
