| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-10-09 |
| タイトル |
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|
タイトル |
Cord Blood RSV-Neutralizing Antibodies and Risk of Hospitalization for RSV-Associated Acute Respiratory Infection in Vietnamese Children: A Case–Cohort Study |
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言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
respiratory syncytial virus |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
neutralizing antibodies |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cord blood |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
maternal antibodies |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
infants |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
maternal immunization |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
case–cohort study |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Toizumi, Michiko
Yamagata, Yutaro
Nguyen, Hien Anh Thi
Otomaru, Hirono
Le, Hoang Huy
Moriuchi, Hiroyuki
Eleouet, Jean-Francois
Rameix-Welti, Marie-Anne
Takeda, Makoto
Do, Hung Thai
Yoshida, Lay-Myint
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background: Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in children, particularly severe during infancy. Maternal RSV-specific neutralizing antibodies (nAbs), transferred via the placenta, may provide protection in early infancy, but the extent and duration of protection remain uncertain. Objective: We investigated the association between cord blood RSV-A nAb levels and the risk of hospitalization due to RSV-associated acute respiratory infection (RSV-ARI) by 24 months of age. Methods: We conducted a case–cohort study nested within a birth cohort in Nha Trang, Vietnam. From the full cohort (n = 1977), a random subcohort of 392 infants and all 66 infants hospitalized for RSV-ARI by age 24 months were included for RSV-A nAb testing. RSV-A nAb titers at birth were categorized into three groups in the subcohort (low: lowest quartile; middle; interquartile; high: highest quartile). Weighted Cox proportional hazards regression was used to estimate hazard ratios (HRs) for RSV-ARI hospitalization. Results: The incidence of RSV-ARI hospitalization was 17.92 per 1000 person-years by 24 months, and 25.40 per 1000 person-years among infants aged <12 months. Among infants aged <6 months, those in the low nAb group had a significantly higher risk of hospitalization compared to the middle nAb group (adjusted HR: 4.05; 95% CI: 1.51–10.89). Maternal anemia was consistently associated with increased risk. Conclusions: Lower RSV-nAb titers at birth were associated with an increased risk of RSV-ARI hospitalization during early infancy. These findings support the importance of maternal immunization strategies to enhance infant protection against RSV. |
|
言語 |
en |
| 書誌情報 |
en : Vaccines
巻 13,
号 9,
p. art. no. 963,
発行日 2025-09-11
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| 出版者 |
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|
出版者 |
MDPI |
|
言語 |
en |
| ISSN |
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|
収録物識別子タイプ |
EISSN |
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収録物識別子 |
2076-393X |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.3390/vaccines13090963 |
| 権利 |
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|
権利情報 |
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
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言語 |
en |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Vaccines, 13(9), art. no. 963; 2025 |
|
言語 |
en |
V13_963.pdf (1.5 MB)
