| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-10-14 |
| タイトル |
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|
タイトル |
Sustained humoral immunity in the patients recovered from severe fever with thrombocytopenia syndrome |
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言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
SFTS |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Humoral immunity |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Neutralizing antibody |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Memory B cells |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Kubo, Ryotaro
Yoshikawa, Rokusuke
Fujii, Yuji
Kawasak,i Takumi
Takazono, Takahiro
Izumikawa, Koichi
Ariyoshi, Koya
Mukae, Hiroshi
Yasuda, Jiro
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| 抄録 |
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内容記述タイプ |
Other |
|
内容記述 |
Background: Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne viral disease with a mortality rate of 10–30%; however, effective vaccines and therapies for this disease have not yet been developed. Understanding the long-term immune response of recovered individuals is critical for vaccine development and treatment. In this study, we conducted an epidemiological investigation of antibody and memory B cell trends in individuals with SFTS. Methods:Peripheral blood mononuclear cells (PBMCs) and plasma were collected from 16 survivors of SFTS and five healthy controls. SFTS virus (SFTSV)-specific humoral immune responses were assessed using enzyme-linked immunosorbent assay (ELISA), biolayer interferometry (BLI), neutralization assays, and flow cytometry. Results: SFTSV Gn-specific IgG was detected in plasma samples from all patients using ELISA and BLI. All patient plasma samples also presented neutralizing activity against SFTSV infection, and the IC₅₀ values were correlated with ELISA OD values (ρ = 0.700, P = 0.003 and BLI signals (ρ = 0.818, P = 0.0002). Neutralizing antibodies and SFTSV Gn-specific memory B cells were detected in samples from patients up to 6.7 years post-infection. Conclusion: SFTSV-specific humoral immunity, including neutralizing antibodies and memory B cells, can persist in the majority of recovered patients, including those as late as 6.7 years post-infection. This information will be useful for the development of vaccines and antiviral therapies using antibodies against SFTS. |
|
言語 |
en |
| 書誌情報 |
en : Tropical Medicine and Health
巻 53,
号 1,
p. art. no. 127,
発行日 2025-09-30
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| 出版者 |
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|
出版者 |
BioMed Central Ltd |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1349-4147 |
| DOI |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1186/s41182-025-00807-4 |
| 権利 |
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|
権利情報 |
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
|
言語 |
en |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Tropical Medicine and Health, 53(1), art. no. 127; 2025 |
|
言語 |
en |
TMH53_127.pdf (2.2 MB)
