| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-10-14 |
| タイトル |
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タイトル |
Seroprevalence and associated behavioral factors of Toxoplasma gondii infection among pregnant women in Pokhara Valley, Nepal |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Toxoplasma gondii |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
RDT |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ELISA |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Seroprevalence |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Pregnancy |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Risk factors |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Nepal |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Thapa, Mamata
Gompo, Tulsi Ram
Sugi, Tatsuki
Asada, Masahito
Arima, Hiroaki
Pandey, Kishor
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background: Toxoplasma gondii is a protozoan parasite that can cause congenital infections with serious health implications. In pregnant women, T. gondii infection poses significant risks, including miscarriage, stillbirth, and congenital abnormalities in the fetus. The burden of toxoplasmosis is often underrecognized in many developing countries, including Nepal, where awareness and routine screening are limited. This study was aimed at determining the prevalence of T. gondii infection among pregnant women in Pokhara Valley, Nepal, and to identify behavioral risk factors associated with the transmission of this parasite. Methods: A cross-sectional study was conducted at Gandaki Medical College Teaching Hospital, Pokhara Valley, Nepal, from October 2024 to January 2025. A total of 257 serum samples were collected, 91 of which were randomly selected and tested for anti-T. gondii IgG/IgM antibodies using a rapid diagnostic test (RDT) and enzyme-linked immunosorbent assay (ELISA). Sociodemographic and behavioral data were collected using structured questionnaires. Statistical analyses included Fisher’s exact test to assess associations and Cohen’s kappa coefficient to evaluate the consistency between the two diagnostic methods. Results: The RDT detected IgG antibodies in 19.78% (18/91) of the participants, whereas the ELISA identified 38.46% (35/91) of the participants as seropositive. No IgM-positive cases were detected by either method. Compared with the ELISA, the RDT exhibited low sensitivity (34.3%) but high specificity (89.3%), with fair consistency (kappa = 0.26). Cat ownership showed a borderline significant association with seropositivity (OR = 3.79, p = 0.05). Notably, none of the participants demonstrated any knowledge of toxoplasmosis (0%). Conclusions: The findings reveal a significant public health concern. The relatively high seroprevalence of T. gondii, combined with a lack of awareness and identifiable risk factors, underscores the urgent need for educational interventions and prenatal screening programs to reduce the risk of congenital toxoplasmosis in Nepal. |
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言語 |
en |
| 書誌情報 |
en : Tropical Medicine and Health
巻 53,
号 1,
p. art. no. 128,
発行日 2025-09-30
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| 出版者 |
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出版者 |
BioMed Central Ltd |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1349-4147 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1186/s41182-025-00803-8 |
| 権利 |
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|
権利情報 |
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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内容記述タイプ |
Other |
|
内容記述 |
Tropical Medicine and Health, 53(1), art. no. 128; 2025 |
|
言語 |
en |
TMH53_128.pdf (1.3 MB)
