| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-10-16 |
| タイトル |
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|
タイトル |
Identification and characterization of salivary immune complex antigens in oral cancer |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Oral cancer |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Immune complex |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Antigen |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Mass spectrometry |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
C1q ELISA |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Sei, Maria
Kanda, Sayo
Aibara, Nozomi
Hashimura, Rean
Hashizume, Junya
Kutsuna, Yuki Jimbayashi
Naruse, Tomofumi
Omori, Keisuke
Sakai Hironori
Yamada, Shin-ichi
Hasegawa, Takumi
Takeda, Daisuke
Yamakawa, Nobuhiro
Kirita, Tadaaki
Kurosaki, Tomoaki
Miyamoto, Hirotaka
Sato, Kayoko
Kodama, Yukinobu
Nakashima, Mihoko N.
Nakashima, Mikiro
Yanamoto, Souichi
Ohyama, Kaname
|
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Objectives: This study aims to identify antigens incorporated into immune complexes that are associated with oral cancer pathogenesis and to determine their potential clinical applications. Materials and methods: In this study, immune complexome analysis was performed on saliva samples from 66 patients with oral cancer and 40 controls. Immune complexome analysis is an original method for the comprehensive identification of immune complex antigens in body fluids by liquid chromatography-mass spectrometry. Results: We identified 24 IC-antigens that were significantly elevated in early-stage oral cancer compared with the controls, suggesting their potential as indicators for oral cancer. Four IC-antigens (ALOX5, B3GALT6, LAMA4, POLA1) were expressed at significantly higher levels in advanced-stage disease, indicating their involvement in cancer progression. Survival analysis revealed that high levels of POLA1 were associated with lower survival rates. Most of these proteins were reported to be involved in cancer progression and cell proliferation. Conclusion: These findings support the formation of disease-characteristic immune complexes in oral cancer and highlight the potential of immune complexome analysis in saliva for understanding oral cancer pathogenesis and therapeutic targets. |
|
言語 |
en |
| 書誌情報 |
en : Clinical Oral Investigations
巻 29,
号 10,
p. art. no. 482,
発行日 2025-09-29
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| 出版者 |
|
|
出版者 |
Springer Nature |
|
言語 |
en |
| ISSN |
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|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1436-3771 |
| DOI |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1007/s00784-025-06549-1 |
| 権利 |
|
|
権利情報 |
© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025. This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00784-025-06549-1. |
|
言語 |
en |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Clinical Oral Investigations, 29(10), art. no. 482; 2025 |
|
言語 |
en |
COI29_482.pdf (1.9 MB)
Supplemental data.xlsx (1.5 MB)
