| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-10-21 |
| タイトル |
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|
タイトル |
Presensitization Accelerates Antibody-Mediated Rejection in Mouse Intestinal Transplantation |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Antibody-mediated rejection |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Capillaritis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Donor-specific antibody |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Intestinal transplantation |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Mice |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Presensitization |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Skin transplantation |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Fujita, Takuro
Matsushima, Hajime
Kosaka, Taichiro
Miyamoto, Daisuke
Soyama, Akihiko
Hara, Takanobu
Adachi, Tomohiko
Kanetaka, Kengo
Eguchi, Susumu
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Introduction: The presence of donor-specific antibodies (DSAs) is a risk factor for antibody-mediated rejection (AMR) in the context of organ transplantation. However, the mechanisms and clinical characteristics of AMR in intestinal transplantation remain poorly understood, largely due to a lack of suitable animal models. In the present study, we performed intestinal transplantation in presensitized murine recipients as a model of AMR to better understand how this phenomenon contributes to graft rejection. Methods: Skin from donor B6 mice was grafted onto the backs of recipient C3H mice. The presensitized C3H mice then received intestinal allografts from B6 mice 14 ds later. The presensitized and nonsensitized mice were compared in terms of their circulating DSAs levels and their intestinal allograft characteristics at various time points. Results: Flow cytometric analysis showed that circulating DSA levels increased over time in the presensitized recipients. Moreover, the presensitized recipients exhibited more severe intestinal graft rejection at day 4 post-transplantation than the nonsensitized mice. Although immunostaining revealed no significant difference in the numbers of infiltrating CD4+ and CD8+ cells between the groups post-transplantation, the numbers of infiltrating CD20+ and CD68+ cells were significantly higher in the presensitized recipients. Furthermore, C3 and C4 deposition on the microvascular endothelium of intestinal allografts and capillaritis were observed after transplantation. Conclusions: We successfully established a presensitized mouse model of AMR in the context of intestinal transplantation. Our model will be valuable in elucidating the mechanisms underlying AMR and exploring strategies for managing this phenomenon to improve the outcomes of intestinal transplantation. |
|
言語 |
en |
| 書誌情報 |
en : Journal of Surgical Research
巻 315,
p. 390-399,
発行日 2025-10-10
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| 出版者 |
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出版者 |
Elsevier Inc |
|
言語 |
en |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
00224804 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1016/j.jss.2025.09.060 |
| 権利 |
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|
権利情報 |
© 2025 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/). |
|
言語 |
en |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Journal of Surgical Research, 315, pp.390-399; 2025 |
|
言語 |
en |
JSR315_390.pdf (10.7 MB)
