| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-10-28 |
| タイトル |
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タイトル |
Low-intensity muscle contraction exercise reduces pain sensitivity by modulating peripheral pathology and spinal sensitization in end-stage knee osteoarthritis rats |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
osteoarthritis |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
pain |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
peripheral pathology |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
central sensitization |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
low-intensity muscle contraction exercise |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Motokawa, Satoko
Sakamoto, Junya
Sasaki, Ryo
Nishi, Yuki
Honda, Yuichiro
Takahashi, Ayumi
Okita, Minoru
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Introduction: This study evaluated the effects of low-intensity muscle contraction exercise on pain sensitivity, peripheral pathology, and central sensitization in the spinal dorsal horn in a rat model of end-stage knee osteoarthritis (OA) induced by monosodium iodoacetate (MIA). Methods: Sixty-two male Wistar rats were assigned to three groups: OA, Exercise, and Sham. The Exercise group underwent quadriceps muscle contractions induced by electrical stimulation (50 Hz, 250 µs, 2–3 mA) with a duty cycle of 1:2 (2 s On, 4 s Off) for 20 min daily, five days per week, from day 29 to day 56 post-MIA administration. Pain sensitivity was assessed by measuring knee joint pressure pain thresholds (PPT) and paw withdrawal thresholds using von Frey filaments. Histological and immunohistochemical analyses of the knee joint and spinal cord included toluidine blue staining, tartrate-resistant acid phosphatase staining, and markers for CD68, CD11c, CD206, osteoclasts, nerve growth factor (NGF), calcitonin gene-related peptide (CGRP), and phosphorylated NR1 (pNR1). Results: Knee joint PPTs were significantly higher in the Exercise group after day 35, accompanied by reductions in CD68-, CD11c-positive cells, NGF-positive cells, CGRP-positive fibers, osteoclasts, and pNR1-positive cells, as well as an increase in CD206-positive cells, compared to the OA group. Discussion: Despite no significant changes in cartilage or subchondral bone degeneration, these findings suggest that low-intensity muscle contraction exercise alleviates pain sensitivity by modulating peripheral pathology and central sensitization. This study highlights the potential of therapeutic exercise as a strategy for OA pain management. |
|
言語 |
en |
| 書誌情報 |
en : Frontiers in Pain Research
巻 6,
p. art. no. 1644177,
発行日 2025-09-29
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| 出版者 |
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出版者 |
Frontiers Media SA |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2673-561X |
| DOI |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.3389/fpain.2025.1644177 |
| 権利 |
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権利情報 |
© 2025 Motokawa, Sakamoto, Sasaki, Nishi, Honda, Takahashi and Okita. This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
|
言語 |
en |
| 著者版フラグ |
|
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
|
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内容記述タイプ |
Other |
|
内容記述 |
Frontiers in Pain Research, 6, art. no. 1644177; 2025 |
|
言語 |
en |
FPR6_1644177.pdf (1.1 MB)
