| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-11-11 |
| タイトル |
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|
タイトル |
Anti–early antigen Epstein-Barr virus titer and atherosclerosis in relation to vascular endothelial growth factor (VEGF) polymorphism rs3025039 among older Japanese individuals |
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言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Angiogenesis |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Atherosclerosis |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
VEGF |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
EB virus |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
SNP |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
rs3025039 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Shimizu, Yuji
Yamanashi, Hirotomo
Kawashiri, Shin-Ya
Noguchi, Yuko
Sasaki, Nagisa
Nakamichi, Seiko
Arima, Kazuhiko
Nagata, Yasuhiro
Maeda, Takahiro
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Background: Epstein-Barr (EB) virus infection stimulates the production of vascular endothelial growth factor (VEGF), which contributes to the progression of angiogenesis. Angiogenesis plays an important role in the development of atherosclerosis. Since serum anti-early antigen EB virus IgG (EBV EA-IgG) titer is a sign of active EB virus infection, EBV EA-IgG titer could be associated with atherosclerosis. The number of minor (T) alleles in VEGF polymorphism rs3025039 has been reported to be inversely associated with serum VEGF concentration, suggesting that rs3025039 might have a strong influence on the association between EBV EA-IgG titer and atherosclerosis. By focusing on the role of VEGF in the development of atherosclerosis, this study aimed to investigate the association between active EB virus infection and atherosclerosis. Methods: A cross-sectional study of 2,661 older Japanese individuals aged 60–89 years who participated in annual health check-ups during 2017–2019 was conducted. Logistic regression was used to evaluate the association between EBV EA-IgG titer and atherosclerosis in relation to rs3025039 genotype. The influence of rs3025039 (T) allele carrier status on the association between EBV EA-IgG titer and atherosclerosis was also evaluated by using logistic regression. Results: Among rs3025039 CC-homozygotes, with the lowest EBV EA-IgG titer tertile as the reference, the multivariable odds ratio (95% confidence interval) was 1.11 (0.82, 1.50) for the medium tertile and 1.07 (0.78, 1.47) for the high tertile. Among rs3025039 (T) allele carriers, the corresponding values were 1.44 (0.88, 2.36) and 1.88 (1.15, 3.05), respectively. There was a significant interaction between rs3025039 (T) allele carrier status and the association between EBV EA-IgG titer and atherosclerosis (adjusted p = 0.0497). Conclusion: EBV EA-IgG titer was significantly positively associated with atherosclerosis only among participants who are genetically less likely to have progressive angiogenesis. An angiogenesis-related genetic factor was revealed as a determinant of the association between EBV EA-IgG titer and atherosclerosis. These findings introduce a novel concept that could explain the association between viral infection and atherosclerosis. |
|
言語 |
en |
| 書誌情報 |
en : Environmental Health and Preventive Medicine
巻 30,
号 0,
p. 83-83,
発行日 2025-10-28
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| 出版者 |
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出版者 |
The Japanese Society for Hygiene |
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言語 |
en |
| 出版社別言語 |
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|
言語 |
ja |
|
値 |
日本衛生学会 |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
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収録物識別子 |
1342-078X |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1265/ehpm.25-00334 |
| 権利 |
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|
権利情報 |
© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
|
言語 |
en |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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内容記述タイプ |
Other |
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内容記述 |
Environmental Health and Preventive Medicine, 30, art. no. 83; 2025 |
|
言語 |
en |
EHPM30_83.pdf (728 KB)
