| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-11-17 |
| タイトル |
|
|
タイトル |
Altered expression of autophagy-related molecules and β-catenin in different subtypes of thyroid cancer: co-localization in intranuclear cytoplasmic inclusions |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Autophagy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
β-catenin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
P62 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
LC3B |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Intranuclear cytoplasmic inclusion |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Sailaubekova, Yerkezhan
Matsuda, Katsuya
Akazawa, Yuko
Kurohama, Hirokazu
Matsuoka, Yuki
Suzuki, Keiji
Kerimbayeva, Adiya
Kondo, Hisayoshi
Nguyen, Van Phu Thang
Nguyen, Thi Ngoc Anh
Nguyen, Thi Nhung
Satoh, Shinya
Shindo, Hisakazu
Yamashita, Hiroyuki
Nakashima, Masahiro
|
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
This study aimed to clarify the expression levels of autophagy-related molecules, such as β-catenin, LC3B, and p62, in thyroid carcinoma (TC) cases of different histological types and clinicopathological characteristics. A total of 70 surgically resected thyroid nodules, including 43 papillary thyroid carcinoma (PTC), and other control groups such as five follicular adenoma (FA), five hyalinizing trabecular tumor (HTT), five follicular TC (FTC), six poorly differentiated TC (PDTC), and six anaplastic follicular cell-derived thyroid carcinoma (ATC), were analyzed by dual-color immunofluorescence for β-catenin, LC3B, and p62. Statistical analyses were used to determine the association of autophagy-related molecules with BRAFV600E/TERT promoter mutations, Ki-67 labeling index, and clinicopathological characteristics. p62 immunoreactivity was most frequently observed in PTC, particularly in classical and tall cell subtypes. This protein appeared to co-localize with LC3B and β-catenin in intranuclear cytoplasmic inclusions (INIs) of PTC. Conversely, p62 expression was rarely observed in either FTC or PDTC. The expression levels of p62 and its co-localization with β-catenin and LC3B correlated significantly with the presence of the BRAFV600E mutation. Frequent co-localization of dot-shaped perinuclear β-catenin signals with a component of the trans-Golgi apparatus in tall cell PTC subtype was also observed. This study revealed differences in the expression patterns of β-catenin, LC3B, and p62 among different TC types. Abnormal β-catenin expression may be linked to autophagy dysfunction, which triggers genomic instability and promotes tumor aggressiveness. These autophagy-related molecules may be cooperatively associated with INI formation during PTC carcinogenesis. |
|
言語 |
en |
| 書誌情報 |
en : Endocrine Journal
巻 72,
号 11,
p. 1205-1215,
発行日 2025-11-04
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| 出版者 |
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|
出版者 |
The Japan Endocrine Society |
|
言語 |
en |
| 出版社別言語 |
|
|
言語 |
ja |
|
値 |
日本内分泌学会 |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0918-8959 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1507/endocrj.EJ25-0181 |
| 権利 |
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|
権利情報 |
©The Japan Endocrine Society This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license. https://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
言語 |
en |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Endocrine Journal, 72(11), pp.1205-1215; 2025 |
|
言語 |
en |
EJ72_1205.pdf (9.4 MB)
