| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-11-27 |
| タイトル |
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タイトル |
Crimean-Congo hemorrhagic fever virus NSm protein inhibits the type I interferon signaling by binding to STAT2 |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Yoshikawa, Rokusuke
Sakurai, Yasuteru
Kondo, Sayako
Kimura, Mayuko
Yasuda, Jiro
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The type I interferon (IFN-I) response, which includes IFN-I induction and signaling, plays an important role in a host’s defence against viral infections. Many pathogenic viruses target it to evade the host immunity. Crimean-Congo hemorrhagic fever virus (CCHFV), the causative agent of Crimean-Congo hemorrhagic fever, which features high mortality in humans, has been reported in southeastern Europe, Africa, the Middle East, and Asia. Although a previous study reported that CCHFV antagonizes IFN-I signaling in human cell lines, it is unclear how it inhibits IFN-I signaling. Here we demonstrated that the non-structural protein of CCHFV, NSm, suppresses IFN-I signaling in human cell lines. Furthermore, we discovered that NSm binds to STAT2, an important host protein in IFN-I signaling, and induces its degradation within cells. Taken together, our results imply that NSm suppresses IFN-I signaling by targeting human STAT2. |
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言語 |
en |
| 書誌情報 |
en : PLOS Neglected Tropical Diseases
巻 19,
号 11,
p. art. no. e0013695,
発行日 2025-11-04
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| 出版者 |
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出版者 |
PLOS |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1935-2735 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1371/journal.pntd.0013695 |
| 権利 |
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権利情報 |
© 2025 Yoshikawa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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言語 |
en |
| 著者版フラグ |
|
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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|
内容記述タイプ |
Other |
|
内容記述 |
PLOS Neglected Tropical Diseases, 19(11), art. no. e0013695; 2025 |
|
言語 |
en |
PLOSNTD19_e0013695.pdf (2.3 MB)
