| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-11-27 |
| タイトル |
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タイトル |
Tiger deaths in Vietnam due to infection with H5N1 highly pathogenic avian influenza virus bearing mutations associated with mammalian host adaptation |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Influenza |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Highly pathogenic |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
H5N1 |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Tiger |
| キーワード |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Vietnam |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Amano, Murasaki
Nga, Nguyen Thi
Le, Khanh Hang Nguyen
Tho, Nguyen Dang
Diep, Nguyen Thi
Vui, Dam Thi
Hasebe, Futoshi
Abe, Haruka
Mai, Le Thi Quynh
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Recently, infections with the H5N1 subtype of highly pathogenic avian influenza virus (H5N1-HPAIV) in mammals have been reported worldwide, including in cows in the United States and successive human cases in Cambodia. In Vietnam, 47 tigers and three leopards died from H5N1-HPAIV infection between August and October 2024. This study aimed to determine the origin of the H5N1 strains that infect tigers in Vietnam and to identify specific mutations associated with mammalian infection. Specimens were collected from tigers that died of suspected H5N1-HPAIV infection in southern Vietnam in September-October 2024. RNA was extracted and subjected to whole-genome sequencing. Time-stamped phylogenetic analysis was performed using H5N1 sequences recently detected in Vietnam and neighbouring countries. Phylogenetic results revealed that the strain found in tigers (Tiger H5N1 strain) belonged to clade 2.3.2.1e and has been genetically close to the H5N1-HPAIV lineage responsible for ongoing human infections in Cambodia since 2023. Tiger H5N1 strains harboured several amino acid substitutions associated with mammalian host adaptation or transmissibility, such as E627K in polymerase basic protein 2, similar to the Cambodian human H5N1 strains. This mammalian-adapted H5N1 lineage should be continuously monitored in poultry and mammals, including humans, in Vietnam to prevent further transmission. |
|
言語 |
en |
| 書誌情報 |
en : Emerging Microbes & Infections
巻 14,
号 1,
p. art. no. 2582252,
発行日 2025-11-11
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| 出版者 |
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出版者 |
Taylor and Francis Ltd |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2222-1751 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1080/22221751.2025.2582252 |
| 権利 |
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|
権利情報 |
© 2025 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. |
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言語 |
en |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
|
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内容記述タイプ |
Other |
|
内容記述 |
Emerging Microbes and Infections, 14(1), art. no. 2582252; 2025 |
|
言語 |
en |
EMI14_2582252.pdf (1 MB)
