| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-11-28 |
| タイトル |
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|
タイトル |
Differential impact of graft-versus-host disease on post-transplant outcomes of chronic myelomonocytic leukemia according to transplant procedures |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Chronic myelomonocytic leukemia |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Allogeneic hematopoietic stem cell |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
transplantation |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Graft-versus-host disease |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Graft-versus-leukemia effect |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Itonaga, Hidehiro
Miyazaki, Yasushi
Fujioka, Machiko
Kurosawa, Shuhei
Nagata, Yasunobu
Shimazu, Yutaka
Ueda, Tomoaki
Uchida, Naoyuki
Doki, Noriko
Nishida, Tetsuya
Asada, Noboru
Tanaka, Masatsugu
Takada, Satoru
Sakurai, Masatoshi
Kurokawa, Mineo
Yoshimitsu, Makoto
Kanda, Yoshinobu
Ichinohe, Tatsuo
Atsuta, Yoshiko
Tachibana, Takayoshi
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) provides curative outcomes for chronic myelomonocytic leukemia (CMML). We conducted a retrospective study to clarify the protective impact of acute and chronic graft-versus-host disease (aGVHD and cGVHD) on relapse by transplant procedures in 314 CMML patients. Interaction effects of conditioning intensity were observed with aGVHD (Pinteraction=0.181) and cGVHD (Pinteraction=0.256) for the cumulative incidence of relapse (CIR), whereas interaction effects of donor type were not detected with GVHD. In patients with the myeloablative conditioning regimens, the multivariate analysis showed that the development of aGVHD was not associated with overall survival (OS). The development of limited cGVHD correlated with better OS (HR [95 % CI], 0.34 [0.14–0.81]; P = 0.015); and that of extensive cGVHD correlated with better OS (HR, 0.44 [0.21–0.91]; P = 0.026) and lower CIR (HR, 0.28 [0.08–0.94]; P = 0.040). In patients with the reduced-intensity conditioning regimens, the development of grade I-II aGVHD correlated with better OS (HR, 0.39 [0.20–0.76]; P = 0.005) and lower CIR (HR, 0.30 [0.13–0.70]; P = 0.006). The development of extensive cGVHD correlated with better OS (HR, 0.44 [0.20–0.96]; P = 0.039). The present results suggest that the type and severity of GVHD mediating graft-versus-leukemia effects against relapse were influenced by conditioning intensity in CMML patients. |
|
言語 |
en |
| 書誌情報 |
en : Leukemia Research
巻 159,
p. art. no. 108134,
発行日 2025-11-11
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| 出版者 |
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出版者 |
Elsevier Ltd |
|
言語 |
en |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
01452126 |
| DOI |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1016/j.leukres.2025.108134 |
| 権利 |
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|
権利情報 |
© 2025 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/. |
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言語 |
en |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Leukemia Research, 159, art. no. 108134; 2025 |
|
言語 |
en |
LR159_108134.pdf (1.4 MB)
