| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-12-02 |
| タイトル |
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|
タイトル |
LFD implementation uncovers hidden rabies burden: Pre- and post-implementation analysis and comparison with non-implementation sites in the Philippines |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
LFD |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
One health |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Implementation study |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Outbreak |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Time series analysis |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Saito, Nobuo
Lacanilao, Patricia T.
Garcia, Alyssa M.
Inton, Karren L.
Mauhay, Jaira D.
Basinang, Voltaire G.
Fernando, Lea G.
Bernardo, Benedict T.
Dela, Cruz Roel G.
Agapito, Arvin H.
Banaag, Arby B.
Bernardo, Gladys M.
Andres, Jonarel M.
San, Juan Geraldine M.
Tecson, Edwin P.
Balingit, Annie M.
Ongtangco, Joely T.
Lagayana, Maria G.
Cruz, Jeffrey L.
Oridinario, Shella G.
Demetria, Catalino S.
Manalo, Daria L.
Quiambao, Beatriz P.
Kimitsuki, Kazunori
Nishizono, Akira
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Background: Despite accumulating evidence supporting lateral flow devices (LFDs) in rabies diagnosis, their impacts of decentralizing diagnostic capacity on surveillance in endemic settings have not been systematically evaluated. Methods: We established low-resource decentralized rabies diagnostic laboratories in a target area of the Philippines, where rabies testing was previously unavailable, and evaluated both the diagnostic performance of LFD and their impacts on surveillance. Results: Using DFAT (direct fluorescent antibody test) as reference, LFDs performed at the decentralized laboratories showed a sensitivity of 97.0 % and a specificity of 98.2 %. After implementation, the monthly number of confirmed animal rabies cases in the target area increased from 2.09 to 8.65 cases, representing a 4.14-fold increase (p < 0.001), a change not observed in neighboring provinces without LFD implementation. Interrupted time series analysis further supported a significantly increasing trend in case detection after the implementation (coefficient = 0.565, p < 0.001), which was not observed in non-implementation provinces. Through 69 outbreak investigations triggered by LFD-positive cases, 22 unvaccinated human bite victims and 66 exposed animals were additionally identified. However, while case investigations were performed in 54.8 % of cases, integrated One Health investigations involving coordinated actions by local health and veterinary offices were conducted in only 5.6 %. Conclusion: LFD-based decentralization markedly improved case detection and enabled critical outbreak responses at the local level, demonstrating its value for rabies control in endemic settings though sustained One Health approach remains a challenge following the detection of rabid animals using LFD. |
|
言語 |
en |
| 書誌情報 |
en : One Health
巻 21,
p. art. no. 101281,
発行日 2025-11-21
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| 出版者 |
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出版者 |
Elsevier B.V. |
|
言語 |
en |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
23527714 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1016/j.onehlt.2025.101281 |
| 権利 |
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|
権利情報 |
© 2025 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
|
言語 |
en |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
One Health, 21, art. no. 101281; 2025 |
|
言語 |
en |
OH21_101281.pdf (3.2 MB)
