| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-12-09 |
| タイトル |
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|
タイトル |
Radiosensitization Effect of PARP Inhibitor Talazoparib Involves Decreasing Mitochondrial Membrane Potential and Induction of Cellular Senescence |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
γ-irradiation |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
radiosensitization |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
PARPis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
talazoparib |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
senescence |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Saraswat, Barkha
Velu, Ankitha Vadi
Gao, Zhongming
Zhang, Zongxiang
Zhu, Haoyang
Tong, Ying
Masutani, Mitsuko
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPis) with radiation therapy can enhance the sensitivity of cancer cells by inhibiting DNA repair pathways. To determine the most suitable PARP inhibitor for radiosensitization in cancer cells, we compared various types of clinically used PARPis in lung cancer A549 cells. We found that most PARP inhibitors showed radiosensitization effects on A549 cells. ER10 values for talazoparib, olaparib rucaparib, ABT888 and niraparib were 1.5, 1.8, 2.8, 1.4, and 1.4, respectively. Talazoparib showed a radiosensitization effect at its lowest concentration. Talazoparib is a potent PARP inhibitor and has been used in clinical settings for several types of cancer as an anti-cancer agent. We thus focused on how talazoparib causes radiosensitization in lung cancer A549 cells. As a result of the combination of talazoparib and γ-irradiation, we observed an increased level of cellular senescence accompanied by a decrease in mitochondrial membrane potential. When the p21 gene was knocked down, both the decrease in mitochondrial membrane potential and senescence level were attenuated, suggesting that p21 is involved in senescence induction after γ-irradiation combined with talazoparib treatment. Taken together, we showed that PARP inhibitor talazoparib treatment in combination with γ-irradiation causes cellular senescence in lung cancer cells, involving p21 function. |
|
言語 |
en |
| 書誌情報 |
en : Current Issues in Molecular Biology
巻 47,
号 11,
p. art. no. 908,
発行日 2025-11-01
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| 出版者 |
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出版者 |
MDPI |
|
言語 |
en |
| ISSN |
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|
収録物識別子タイプ |
EISSN |
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収録物識別子 |
1467-3045 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.3390/cimb47110908 |
| 権利 |
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|
権利情報 |
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
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言語 |
en |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Current Issues in Molecular Biology, 47(11), art. no. 908; 2025 |
|
言語 |
en |
CIMB47_908.pdf (4.7 MB)
