| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-12-18 |
| タイトル |
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|
タイトル |
Early determination of the dorsal-ventral axis in endochondral ossification in mice |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
bone development |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
endochondral ossification |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
mesenchymal condensation |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cartilage anlage |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
dorsal-ventral axis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
dorsoventral axis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
lineage tracing |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Fgfr3 |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Dlx5 |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
skeletal progenitor cells |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Wu, Sixun
Matsumoto, Hirotaka
Morita, Jumpei
Yamabe, Mina
Noguchi, Azumi
Ohba, Shinsuke
Ono, Noriaki
Matsushita, Yuki
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Endochondral ossification is a highly coordinated process involving distinct progenitor cell populations within the mesenchymal condensation and subsequent cartilage anlage and perichondrium, all of which drive skeletal formation. Cell-type specific lineage tracing conducted to understand fetal bone development has revealed various fates of early skeletal cells. However, the underlying continuous and precise cellular dynamics of fetal skeletal cells, particularly along the dorsoventral axis, remain unclear. Here, we show that spatiotemporally specific skeletal progenitor cells in the early developmental stage contribute to the dorsal-ventral axis in a manner that is strictly determined during initial developmental stages. Lineage-tracing experiments using Fgfr3-creER and Dlx5-creER lines revealed that Fgfr3+ cells in mesenchymal condensation exclusively contributed to hypertrophic chondrocytes and the dorsal side of the resting and proliferating zones within the cartilage anlage. These cells made dorsal-restricted contributions to skeletal development, including growth plate chondrocytes, trabecular and cortical osteoblasts, and bone marrow stromal cells. Functional ablation of Fgfr3+ cells using the Rosa26iDTA (inducible diphtheria toxin fragment A) allele during the mesenchymal condensation stage caused severe disruption in long-bone development, underscoring its indispensable role in initiating skeletal growth. Collectively, these findings suggest that the condensation stage is pivotal for the formation of skeletal progenitors and dorsoventral patterning during bone development. Understanding these mechanisms will provide insight into skeletal growth disorders and therapeutic strategies for bone regeneration. |
|
言語 |
en |
| 書誌情報 |
en : Journal of Bone and Mineral Research
巻 40,
号 12,
p. 1385-1396,
発行日 2025-06-23
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| 出版者 |
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|
出版者 |
Oxford University Press |
|
言語 |
en |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0884-0431 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1093/jbmr/zjaf086 |
| 権利 |
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|
権利情報 |
© The Author(s) 2025. Published by Oxford University Press on behalf of the American Society for Bone and Mineral Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
|
言語 |
en |
| 著者版フラグ |
|
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
|
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内容記述タイプ |
Other |
|
内容記述 |
Journal of Bone and Mineral Research, 40(12), pp.1385-1396: 2025 |
|
言語 |
en |
JBMR40_1385.pdf (2.7 MB)
