| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-12-22 |
| タイトル |
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|
タイトル |
Enhancing exercise tolerance in interstitial lung disease with high‐flow nasal cannula oxygen therapy: A randomized crossover trial |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
endurance time |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
gas flow |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
high-flow nasal cannula |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
interstitial lung disease |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
oxygen |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Yanagita, Yorihide
Arizono, Shinichi
Yokomura, Koshi
Ito, Kumiko
Machiguchi, Hikaru
Tawara, Yuichi
Katagiri, Norimasa
Iida, Yuki
Nakatani, Eiji
Tanaka, Takako
Kozu, Ryo
|
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Background and Objective: Interstitial lung disease (ILD) is characterized by dyspnoea on exertion and exercise-induced hypoxaemia. High-flow nasal cannula (HFNC) therapy reduces the respiratory workload through higher gas flow and oxygen supplementation, which may affect exercise tolerance. This study aimed to examine the effects of oxygen and gas flow rates through HFNC therapy on exercise tolerance in ILD patients. Methods: We conducted three-treatment crossover study. All ILD patients performed the exercises on room air (ROOM AIR setting: flow, 0 L/min; fraction of inspired oxygen [FiO2], 0.21), HFNC (FLOW setting: flow 40 L/min, FiO2 0.21), and HFNC with oxygen supplementation (FLOW + OXYGEN setting: flow 40 L/min, FiO2 0.6). The primary endpoint was the endurance time, measured using constant-load cycle ergometry exercise testing at a peak work rate of 80%. Results: Twenty-five participants (10 men, 71.2 ± 6.7 years) were enrolled. The increase in exercise duration between the ROOM AIR and FLOW was 46.3 s (95% CI, −6.1 to 98.7; p = 0.083), and the FLOW and FLOW + OXYGEN was 91.5 s (39.1–143.9; p < 0.001). The percutaneous oxygen saturation (SpO2) at rest was significantly higher with the FLOW + OXYGEN setting than with the ROOM AIR and FLOW settings, and the difference persisted during exercise. At equivalent time points during exercise, the SpO2 with the FLOW setting was significantly higher than that with the ROOM AIR setting. Conclusio: Oxygen supplementation in HFNC therapy improved exercise tolerance and SpO2. We found that gas flow alone did not improve exercise tolerance, but improved SpO2 during exercise. |
|
言語 |
en |
| 書誌情報 |
en : Respirology
巻 29,
号 6,
p. 497-504,
発行日 2024-02-22
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| 出版者 |
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出版者 |
Wiley |
|
言語 |
en |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1323-7799 |
| DOI |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1111/resp.14684 |
| 権利 |
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|
権利情報 |
© 2024 Asian Pacific Society of Respirology. This is the peer reviewed version of the following article: Respirology, 29(6), pp.497-504; 2024, which has been published in final form at https://doi.org/10.1111/resp.14684. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
|
言語 |
en |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Respirology, 29(6), pp.497-504; 2024 |
|
言語 |
en |
R29_497.pdf (1.2 MB)
