| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-01-13 |
| タイトル |
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|
タイトル |
Remdesivir as a potent antiviral against prototype and current epidemic Oropouche virus strains (BeAn19991 and PE-IAM4637) |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Oropouche virus |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Reporter virus |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Antiviral drug |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Remdesivir |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Yoshikawa, Rokusuke
Ishii, Yoshiyasu
Sano, Naomi
Yasuda, Jiro
|
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
The Oropouche virus (OROV), an orthobunyavirus transmitted by biting midges, is the causative agent of Oropouche fever, which has caused multiple outbreaks in South and Central America. During the most recent epidemic in 2023–2025, >25,000 laboratory-confirmed cases were reported in Brazil, and no licensed antivirals have been reported to be effective date. In this study, we generated a recombinant OROV-expressing enhanced green fluorescent protein (rOROV/GFP) to facilitate rapid and sensitive antiviral evaluation. Growth kinetics demonstrated that rOROV/GFP replicated less efficiently than wild-type rOROV and that the historical prototype strain (BeAn19991) exhibited higher replication efficiency than the recent epidemic isolate (PE-IAM4637) in both Vero E6 and Huh7 cells. Using this system, we evaluated the antiviral activity of ribavirin, favipiravir (T-705), and remdesivir against OROV. All three compounds inhibited OROV replication in a dose-dependent manner, with remdesivir showing the greatest potency (IC₅₀ values of 0.31 µM). Taken together, our findings highlight remdesivir as a promising candidate for the treatment of Oropouche fever caused by OROV. Furthermore, we established rOROV/GFP as a powerful tool for antiviral drug screening. |
|
言語 |
en |
| 書誌情報 |
en : Virus Research
巻 363,
p. art. no. 199680,
発行日 2026-01-06
|
| 出版者 |
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|
出版者 |
Elsevier B.V. |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
01681702 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.virusres.2025.199680 |
| 権利 |
|
|
権利情報 |
© 2025 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
|
言語 |
en |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Virus Research, 363, art. no. 199680; 2026 |
|
言語 |
en |
VR363_199680.pdf (6 MB)
