| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-01-13 |
| タイトル |
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タイトル |
Flexible Loading Phase Treat-and-Extend Regimen with Faricimab for Neovascular Age-Related Macular Degeneration: A Real-World Study |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
faricimab |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
flexible loading phase |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
neovascular age-related macular degeneration |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
polypoidal choroidal vasculopathy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
real-world study |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
treat-and-extend |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Machida, Akira
Kurihara, Junko
Hirata, Yuki
Machida, Eriko
Murakami, Ryuya
Oka, Akari
Yoneda, Ai
Tsuiki, Eiko
Oishi, Akio
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background/Objectives: We aimed to evaluate the efficacy of a flexible loading-phase treat-and-extend regimen using faricimab, in which the number of loading-phase intravitreal injections was tailored to individual disease activity. Methods: This observational cohort study included 50 treatment-naïve eyes with neovascular age-related macular degeneration, treated with faricimab in Japan; approximately half of the eyes had polypoidal choroidal vasculopathy (PCV). Disease activity after one injection was assessed at the second visit (4 weeks later) to determine the treatment interval for subsequent injections. The primary outcome measure was the injection interval and visual/anatomical outcomes at 1 year after treatment initiation. Results: Of the 50 eyes, 43 completed a 1-year follow-up, including 27 eyes with PCV. The mean logarithm of the minimum angle of resolution best-corrected visual acuity improved from 0.35 ± 0.32 to 0.19 ± 0.3 over 1 year. Overall, 60.5% achieved 16-week intervals, and 74.4% reached intervals of ≥12 weeks. A shorter loading phase (two or three injections) was associated with fewer total injections and higher rates of fluid resolution, without compromising visual outcomes. The presence of PCV and ellipsoid zone disruption were identified as risk factors for failure to extend treatment intervals beyond 16 weeks. Conclusions: A flexible loading-phase treat-and-extend regimen using faricimab yields outcomes comparable to those of the TENAYA protocol, with fewer injections, despite the high proportion of eyes with PCV. This simple approach is straightforward in design and may reduce treatment burden while maintaining efficacy. |
|
言語 |
en |
| 書誌情報 |
en : Biomedicines
巻 13,
号 12,
p. art. no. 2909,
発行日 2025-11-27
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| 出版者 |
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出版者 |
MDPI |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2227-9059 |
| DOI |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.3390/biomedicines13122909 |
| 権利 |
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|
権利情報 |
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/) |
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言語 |
en |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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|
内容記述タイプ |
Other |
|
内容記述 |
Biomedicines, 13(12), art. no. 2909; 2025 |
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言語 |
en |
B13_2909.pdf (494 KB)
