| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-01-19 |
| タイトル |
|
|
タイトル |
Effect of Pathological Response After Neoadjuvant Chemotherapy on Long-term Outcomes in Locally Advanced Colorectal Cancer: A Japanese Multicenter Study |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Neoadjuvant chemotherapy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
colorectal |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cancer |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
adjuvant chemotherapy |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
NODA, KEISUKE
TOMINAGA, TETSURO
HASHIMOTO, SHINTARO
YAMASHITA, MARIKO
MARUTA, HIROSHI
TEI, SHOKO
ONO, RIKA
ISHII, MITSUTOSHI
OISHI, KAIDO
INAO, AYANO
MORIYAMA, MASAAKI
ONODA, TAKASHI
SHIRAISHI, TOSHIO
KUNIZAKI, MASAKI
NONAKA, TAKASHI
MATSUMOTO, KEITARO
|
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Background/Aim: Few studies have examined how the response to neoadjuvant chemotherapy (NAC) for locally advanced colorectal cancer affects prognosis. Patients and Methods: A total of 162 patients who received NAC followed by radical resection with curative intent between April 2016 and December 2024 were included. Patients were classified into two groups: good response (n=43) and poor response (n=119). Clinicopathological characteristics and prognosis were compared between the groups. Results: The good response group had a lower rate of combined resection of adjacent organs (11.6% vs. 25.2%, p=0.046), higher clinical N status before NAC (93.0% vs. 71.4%, p=0.002), lower pathological T4 rate (2.3% vs. 23.5%, p<0.001), and less lymphovascular invasion (30.2% vs. 68.9%, p<0.001). Median follow-up duration was 41 months (range=1-66 months). Good responders tended to have better relapse-free survival (RFS; 83.7% vs. 70.5%; p=0.092). Overall survival was similar between the groups (88.6% vs. 78.6% p=0.629). In the poor response group, patients who received adjuvant chemotherapy had significantly better RFS than those who did not (67.3% vs. 70.1%, p<0.05). Conclusion: Patients with a good response to NAC tended to have a better prognosis. Adjuvant chemotherapy might improve outcomes in patients with poor response to NAC. |
|
言語 |
en |
| 書誌情報 |
en : Anticancer Research
巻 46,
号 1,
p. 327-336,
発行日 2025-12-30
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| 出版者 |
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|
出版者 |
International Institute of Anticancer Research |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0250-7005 |
| DOI |
|
|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.21873/anticanres.17947 |
| 権利 |
|
|
権利情報 |
© 2026 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. |
|
言語 |
en |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Anticancer Research, 46(1), pp.327-336; 2025 |
|
言語 |
en |
AR46_327.pdf (475 KB)
