| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-01-29 |
| タイトル |
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|
タイトル |
Metabolic positron emission tomography imaging and tumor growth inhibition during the Q neuron-induced hibernation-like state in mice |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Hibernation |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Q neuron |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Positron emission tomography |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Fluorodeoxyglucose |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Thiamine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Amino acid derivatives |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Nomura, Shoko
Arakaki, Wakiko
Kato, Akari
Fujie, Naomi
Ishikawa, Kiyomi
Wataki, Ayaka
Ono, Hiroaki
Tahara, Tsuyoshi
Wada, Yasuhiro
Watanabe, Yasuyoshi
Doi, Hisashi
Sunagawa, Genshiro A.
Mukai, Hidefumi
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| 抄録 |
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内容記述タイプ |
Other |
|
内容記述 |
To the best of our knowledge, this is the first positron emission tomography (PET) study using a Q neuron–induced hypothermia and hypometabolism (QIH) mouse model, which is a synthetic hibernation-like state triggered by neural stimulation. We investigated changes in the in vivo dynamics of various essential nutrients and bioactive substances during hibernation using three types of metabolic probes: the glucose derivative [18F]FDG (fluorodeoxyglucose), amino acid derivative L-m-[11C]tolylalanine, and vitamin B1 derivative [11C]thiamine. We found that cardiac glucose metabolism was significantly reduced during the QIH state. Both vitamin B1 and the amino acid derivatives exhibited rapid systemic distribution immediately after intravenous administration, which may indicate increased translocation into tissues based on altered circulatory dynamics or vascular wall properties. We also found that the proliferation of subcutaneously inoculated tumors was dramatically suppressed by QIH. Recently, hibernation has increasingly attracted attention because of its advantages, including reduced oxygen and energy consumption, that can mitigate organ damage. Notably, hibernation-like states may have potential applications in emergency and critical care medicine. Therefore, the advancement of hibernation research using QIH models and highlighted the potential of hibernation-like states for novel applications in cancer therapy and drug delivery. |
|
言語 |
en |
| 書誌情報 |
en : Biochemical and Biophysical Research Communications
巻 800,
p. art. no. 153268,
発行日 2026-01-16
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| 出版者 |
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出版者 |
Elsevier Inc. |
|
言語 |
en |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
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収録物識別子 |
0006291X |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1016/j.bbrc.2026.153268 |
| 権利 |
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|
権利情報 |
© 2026 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by- nc-nd/4.0/). |
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言語 |
en |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Biochemical and Biophysical Research Communications, 800, art. no. 153268; 2026 |
|
言語 |
en |
BBRC800_153268.pdf (6.8 MB)
