| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-01-29 |
| タイトル |
|
|
タイトル |
Identification of novel small chemical compounds that inhibit Ebola virus VP40-mediated virus-like particle production |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Ebola virus |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
VP40 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Chemical compound |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Particle production |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Tsuruta, Tomoko
Mizuta, Satoshi
Izumisawa, Ayako
Yasuda, Jiro
Urata, Shuzo
|
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
The central role of Ebola virus (EBOV) VP40 in nascent virion assembly and budding from infected host cells makes it an important therapeutic target. Previously, we reported two novel chemical compounds (NUSU#1 and NUSU#2) that inhibit EBOV VP40-mediated virus-like particle (VLP) production. In this study, we aimed to develop and identify novel synthetic compounds derived from NUSU#1. Forty-five compounds were synthesized and examined for their effects in vitro. Through cell viability and screening assays that we previously developed and reported, five novel synthesized compounds were selected for their inhibitory effects on EBOV VP40-mediated VLP production. Although none of them showed a stronger inhibitory effect on VLP production than NUSU#1, four of the five selected compounds exhibited a statistically significant reduction in EBOV VP40-mediated VLP production compared with the control treatment using a VLP assay. |
|
言語 |
en |
| 書誌情報 |
en : Virus Research
巻 364,
p. art. no. 199684,
発行日 2026-01-08
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| 出版者 |
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|
出版者 |
Elsevier B.V. |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
01681702 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.virusres.2026.199684 |
| 権利 |
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|
権利情報 |
© 2026 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) |
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言語 |
en |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Virus Research, 364, art. no. 199684; 2026 |
|
言語 |
en |
VR364_199684.pdf (1.3 MB)
