| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-02-05 |
| タイトル |
|
|
タイトル |
Membranous nephropathy and hepatitis secondary to syphilis: a case report and literature review |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Syphilis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Membranous nephropathy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Hepatitis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Neuron-derived neurotrophic factor |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Ashizawa, Kanoko
Uramatsu, Tadashi
Tsuyuki, Tomohisa
Ikemi, Eri
Sakamoto, Ryosuke
Tsuji, Kiyokazu
Morisaki, Tomohito
Matsuoka, Yuki
Nakashima, Masahiro
Katafuchi, Eisuke
Nakayama, Toshiyuki
Ashizawa, Kazuto
Torigoe, Kenta
Kitamura, Mineaki
Muta, Kumiko
Nishino, Tomoya
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Syphilis is a re-emerging infectious disease with diverse clinical manifestations; however, renal and hepatic involvement remains rare and under-recognized. Here, we describe the case of a 58-year-old man who presented with nephrotic syndrome. He had noted bilateral leg edema 1 month prior to presentation. Renal function was preserved; however, serum alkaline phosphatase (ALP) and γ-glutamyl transpeptidase (γ-GT) levels were elevated. Renal biopsy confirmed a diagnosis of membranous nephropathy (MN). In addition to positive results for both the Treponema pallidum antibody and rapid plasma reagin tests, a positive immunohistochemistry result for neuron-derived neurotrophic factor (NDNF), an antigen specific to syphilis-associated MN, suggested MN secondary to syphilis. Syphilitic hepatitis was also considered the likely cause of liver damage. Following antisyphilitic therapy, the nephrotic syndrome entered complete remission, and ALP and γ-GT levels normalized. This case serves as a reminder that renal and hepatic impairments can occur in patients with syphilis. To date, only a few cases of concurrent MN and hepatitis as complications of syphilis have been reported. Among these cases, this is the first reported case of NDNF-positive MN. We present this case along with a review of previously reported cases. |
|
言語 |
en |
| 書誌情報 |
en : CEN Case Reports
巻 15,
号 1,
p. art. no. 29,
発行日 2026-01-21
|
| 出版者 |
|
|
出版者 |
Japanese Society of Nephrology |
|
言語 |
en |
| 出版社別言語 |
|
|
言語 |
ja |
|
値 |
日本腎臓学会 |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2192-4449 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1007/s13730-025-01074-2 |
| 権利 |
|
|
権利情報 |
© The Author(s), under exclusive licence to Japanese Society of Nephrology 2026. This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s13730-025-01074-2 |
|
言語 |
en |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
CEN Case Reports, 15(1), art. no. 29; 2026 |
|
言語 |
en |
CENCR15_29.pdf (2.6 MB)
