| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-02-10 |
| タイトル |
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|
タイトル |
Association between Schistosoma mansoni infection and fecal occult blood in schoolchildren in Mbita, Suba North sub-county, western Kenya |
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言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Schistosoma mansoni |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Fecal occult blood |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Preschool-aged children |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
School-aged children |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Intestinal morbidity |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Biegon, Joy C.
Gachohi, John
Ngetich, Benard C.
Njenga, Sammy M.
Hamano, Shinjiro
Chadeka, Evans Asena
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background: Schistosoma mansoni infection is highly prevalent in sub-Saharan Africa and is associated with significant intestinal morbidity in children. Current monitoring tools primarily assess infection status and intensity, which may underestimate the disease burden. Fecal occult blood (FOB) is a reliable indicator of bowel morbidity; however, its utility in intestinal schistosomiasis remains inadequately characterized. This study aimed to evaluate FOB as a surrogate marker of S. mansoni-induced intestinal morbidity among children in endemic areas of Kenya. Methods: A pre–post intervention study was conducted among preschool-aged (3–5 years) and school-aged (9–14 years) children in the Mbita Health Demographic Surveillance System along the shores and islands of Lake Victoria, Suba North sub-county, western Kenya. A total of 611 children from 10 primary schools were screened for S. mansoni infection before praziquantel treatment, and 584 were re-evaluated 6 weeks post-treatment. In addition to parasitological examination for S. mansoni, FOB testing, malaria diagnosis, point-of-care hemoglobin measurement, and soil-transmitted helminth assessments were performed both before and after treatment. Associations between S. mansoni infection and FOB positivity were analyzed using Pearson’s Chi-square test and logistic regression. Results: S. mansoni infection prevalence was high before treatment, affecting 66.5% of preschool-aged and 77.4% of school-aged children. Among S. mansoni-infected children, more than three-quarters tested positive for FOB. Six weeks after praziquantel treatment, the prevalence of both S. mansoni infection and FOB positivity declined significantly (infection: 19–21%; FOB: 25–29%; P < 0.01). Before treatment, preschool-aged children residing on islands had twice the odds of FOB positivity compared to those on the mainland (AOR = 2.0; 95% CI 1.2–3.4; P = 0.01), although this association was no longer evident post-treatment. Conclusions: Our findings demonstrate a significant association between S. mansoni infection and FOB positivity. These results suggest that FOB testing could be a useful indicator for monitoring treatment-associated reductions in intestinal morbidity due to S. mansoni in endemic settings. |
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言語 |
en |
| 書誌情報 |
en : Tropical Medicine and Health
巻 54,
号 1,
p. art. no. 23,
発行日 2026-01-26
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| 出版者 |
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|
出版者 |
BioMed Central Ltd |
|
言語 |
en |
| ISSN |
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|
収録物識別子タイプ |
EISSN |
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収録物識別子 |
1349-4147 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1186/s41182-025-00814-5 |
| 権利 |
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|
権利情報 |
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
|
言語 |
en |
| 著者版フラグ |
|
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Tropical Medicine and Health, 54(1), art. no. 23; 2026 |
|
言語 |
en |
TMH54_23.pdf (1.1 MB)
