| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-03-06 |
| タイトル |
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タイトル |
Runx2 in the Perichondrial Osteoblasts Enhances Terminal Differentiation of Chondrocytes Through Nell1 Induction |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
Runx2 |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
perichondrium |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
chondrocyte differentiation |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Nell1 |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
endochondral ossification |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
terminal hypertrophic chondrocytes |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Qin, Xin
Jiang, Qing
Wu, Longfei
Yabuta, Suemi
Sakane, Chiharu
Matsuo Yuki
Zhang, Ziheng
Komori, Hisato
Zhang, Manyu
Ito, Kosei
Komori, Toshihisa
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Runx2 plays essential roles in osteoblast differentiation and chondrocyte maturation. Runx2 in the perichondrium has been reported to inhibit chondrocyte maturation through Fgf18 induction. To further investigate the functions of Runx2 in the perichondrium, we generated Runx2fl/−Cre mice by crossing Runx2fl/+, Runx2+/−, and 2.3-kb Col1a1 Cre mice and compared them with Runx2fl/− mice at E15.5, when the endochondral bones were cartilaginous. Skeletal preparation of the upper limbs in Runx2fl/−Cre mice showed reduced mineralization of the humerus and scapula, and histological analysis of the femurs showed delays in the terminal differentiation of chondrocytes, as indicated by the absence of mineralization and Spp1 expression in the cartilage and osteoblast differentiation in the perichondrium, compared to those in Runx2fl/− mice. mRNA sequence analysis showed that the expression of Nell1, which encodes a secreted protein that enhances chondrocyte maturation, in Runx2fl/−Cre femurs was more than two-fold lower than that in Runx2fl/− femurs. Nell1 expression was reduced in the perichondrium of Runx2fl/−Cre femurs compared to that in Runx2fl/− femurs. Nell1 expression was upregulated by Runx2 overexpression and downregulated by Runx2 siRNA. These findings indicate that Runx2 in perichondrial osteoblasts enhances the terminal differentiation of chondrocytes by inducing Nell1 expression. |
|
言語 |
en |
| 書誌情報 |
en : International Journal of Molecular Sciences
巻 27,
号 3,
p. art. no. 1266,
発行日 2026-01-27
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| 出版者 |
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出版者 |
MDPI |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1422-0067 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.3390/ijms27031266 |
| 権利 |
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|
権利情報 |
© 2026 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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内容記述タイプ |
Other |
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内容記述 |
International Journal of Molecular Sciences, 27(3), art. no. 1266; 2026 |
|
言語 |
en |
IJMS27_1266.pdf (6.5 MB)
