| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-03-13 |
| タイトル |
|
|
タイトル |
Clinical Emergence of Bacteroides-Associated Anaerobic Bacteremia Due to Drug-Resistant Non-Bacteroides fragilis Species: A Multicentric Retrospective Observational Study |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
antibiotic resistance |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Bacteroides species |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
carbapenem resistance |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Kubo, Ryotaro
Iwanaga, Naoki
Nagaoka, Kentaro
Murai, Yushi
Ashizawa, Nobuyuki
Yoshida, Masataka
Takeda, Kazuaki
Ide, Shotaro
Takazono, Takahiro
Kosai, Kosuke
Morinaga, Yoshitomo
Sakamoto, Noriho
Yamamoto, Yoshihiro
Yanagihara, Katsunori
Mukae, Hiroshi
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: Bacteroides species are significant anaerobes that cause intra-abdominal infections. Recent data highlight increasing resistance, specifically to clindamycin (CLDM). However, the precise epidemiology of Bacteroides fragilis and non-fragilis remains unclear. Methods: We retrospectively analyzed 528 obligate anaerobes that were isolated from blood cultures at 6 major Japanese hospitals between 2012 and 2022, with 102 B. fragilis and 72 non-B. fragilis isolates. Clinical characteristics and antimicrobial resistance were assessed. Drug resistance rates over time were analyzed using the Spearman rank correlation test. Results: Compared with the B. fragilis group, non-B. fragilis group demonstrated higher resistance to CLDM (P = .006) and carbapenem (P = .005). Excluding deaths from underlying diseases, the 30-day mortality rate was higher in the non-B. fragilis group than in the B. fragilis group (P = .025). Risk factors in this group included carbapenem resistance (adjusted odds ratio = 7.05, P = .017). Notably, carbapenem (P = .014 vs P = .643) and tazobactam/piperacillin resistance rates (P = .012 vs P = .899) increased over time in the non-B. fragilis group, rather than the B. fragilis group. Conclusions: Non-B. fragilis shows increasing resistance to key antibiotics and is linked to higher 30-day mortality compared with B. fragilis. |
|
言語 |
en |
| 書誌情報 |
en : Open Forum Infectious Diseases
巻 13,
号 2,
p. art. no. ofag047,
発行日 2026-01-30
|
| 出版者 |
|
|
出版者 |
Oxford University Press |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2328-8957 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1093/ofid/ofag047 |
| 権利 |
|
|
権利情報 |
© The Author(s) 2026. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in anyway, and that the work is properly cited. For commercial re-use, please contact reprints@oup.-com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com. https://doi.org/10.1093/ofid/ofag047 |
|
言語 |
en |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Open Forum Infectious Diseases, 13(2), art. no. ofag047; 2026 |
|
言語 |
en |
OFID13_ofag047.pdf (509 KB)
