| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-03-15 |
| タイトル |
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タイトル |
Successful Treatment of Paranasal Sinus Metastasis From Renal Cell Carcinoma With Immune Checkpoint Inhibitors and Radiotherapy: A Case Report |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Yamada, Shota
Matsuo, Tomohiro
Tsuchiyama, Ayaka
Nakanishi, Hiromi
Mitsunari, Kensuke
Ohba, Kojiro
Mochizuki, Yasushi
Imamura, Ryoichi
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Introduction: Renal cell carcinoma (RCC) metastasis to the paranasal sinuses is rare and lacks standard treatment, particularly for unresectable tumors. We report a case of sphenoid sinus metastasis with sarcomatoid differentiation successfully managed with radiation therapy and immunotherapy. Case Presentation: A 59-year-old male who had undergone left radical nephrectomy for RCC 13 years prior presented with acute left eye pain and tinnitus. Contrast-enhanced computed tomography (CT) revealed a hyper vascular sphenoid sinus mass with osseous destruction. Biopsy confirmed metastatic RCC with sarcomatoid differentiation. Given rapid symptom progression, intensity-modulated radiation therapy (39 Gy in 13 fractions) was initiated, followed by immunotherapy with nivolumab and ipilimumab. The patient developed complete blindness, which gradually improved during treatment. Serial CT showed a partial response sustained through four cycles. Subsequent 37 cycles of maintenance nivolumab showed persisting tumor reduction. Conclusion: Radiation with nivolumab and ipilimumab may be effective for unresectable paranasal sinus metastases of RCC. |
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言語 |
en |
| 書誌情報 |
en : IJU Case Reports
巻 9,
号 2,
p. art. no. e70156,
発行日 2026-02-19
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| 出版者 |
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出版者 |
John Wiley and Sons Ltd |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2577-171X |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1002/iju5.70156 |
| 権利 |
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権利情報 |
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2026 The Author(s). IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of Japanese Urological Association. |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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内容記述タイプ |
Other |
|
内容記述 |
IJU Case Reports, 9(2), art. no. e70156; 2026 |
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言語 |
en |
IJUCR9_e70156.pdf (400 KB)
