| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-04-07 |
| タイトル |
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|
タイトル |
A Successful Live Birth After Double Fertility Preservation With Embryo Cryopreservation and MPA Therapy Combined With Hysteroscopic Resection for Metachronous Breast and Endometrial Cancer in Women With Cowden Syndrome: A Case Report |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題URI |
breast cancer |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題URI |
Cowden syndrome |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題URI |
endometrial cancer |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題URI |
fertility preservation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題URI |
hereditary tumors |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Kajimura, Itsuki
Kitajima, Michio
Miura, Shoko
Eishi, Chiaki
Matsuda, Riko
Matsumoto, Kanako
Harada, Ayumi
Kitajima, Yuriko
Hasegawa, Yuri
Matsumoto, Megumi
Matsumoto, Keitaro
Miura, Kiyonori
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Case: Cowden syndrome is an autosomal-dominantly inherited rare condition caused by germline pathogenic variants of the PTEN gene. Multiple tumor development at a younger age in this syndrome may warrant different modalities of fertility preservation. Here we report that women with this syndrome gave successful live birth with frozen–thaw embryo transfer that was cryopreserved before the start of chemotherapy for breast cancer. This woman also suffered from endometrial cancer that developed during hormonal treatment with GnRH agonist and tamoxifen for breast cancer. The lesion was well controlled with oral MPA therapy and hysteroscopic resection. Outcome: She could receive fertility preservation for breast cancer and endometrial cancer before fertility treatment and pregnancy. Conclusion: This is the first report of live births after multiple fertility preservation therapy for metachronous breast and uterine cancer in Cowden syndrome. Appropriate genetic counseling may help the patient's decision making. The treatment plan should be discussed with diverse professionals such as oncologists, reproductive physicians, perinatologists, geneticists, and genetic counselors. |
|
言語 |
en |
| 書誌情報 |
en : Reproductive Medicine and Biology
巻 25,
号 1,
p. art. no. e70035,
発行日 2026-03-05
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| 出版者 |
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|
出版者 |
John Wiley and Sons Ltd |
|
言語 |
en |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1445-5781 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1002/rmb2.70035 |
| 権利 |
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|
権利情報 |
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2026 The Author(s). Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine. |
|
言語 |
en |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Reproductive Medicine and Biology, 25(1), art. no. e70035; 2026 |
|
言語 |
en |
RMB25_e70035.pdf (498 KB)
