| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-04-07 |
| タイトル |
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タイトル |
Antibacterial Effects of Nanobubble Water and Its Potential Application in Healthcare-associated Infection Control |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題URI |
Nanobubble |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題URI |
bacteria |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題URI |
antibacterial effect |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題URI |
in vitro |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題URI |
healthcare-associated infection |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
YOSHIDA, TAKUYA
DOI, RYOICHIRO
KAKU, NORIHITO
BABA, MASAYUKI
IMAI, MAKOTO
MARUTA, HIROSHI
SAKAGUCHI, MIAKO
AKAMATSU, NORIHIKO
TOMINAGA, TETSURO
YANAGIHARA, KATSUNORI
MATSUMOTO, KEITARO
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background/Aim: Healthcare-associated infections (HAIs) remain a major cause of morbidity in hospitalized patients and residents of long-term care facilities. Conventional chemical disinfectants have limitations such as corrosion, toxicity, and economic burden. This study investigated the antibacterial properties of nanobubble water (NBW) as a novel physicochemical disinfection method that does not require chemical additives. Materials and Methods: NBW was generated using four gases–air, nitrogen (N2), oxygen (O2), and carbon dioxide (CO2)– and tested against Escherichia coli (E. coli), Extended-spectrum beta-lactamase (ESBL)-producing E. coli, Staphylococcus aureus, and Methicillin-resistant S. aureus (MRSA). Nanobubble size and stability were analyzed, and time-dependent antibacterial activity was evaluated by colony-forming unit (CFU) assays. Transmission electron microscopy (TEM) was used to assess bacterial ultrastructural changes following NBW exposure. Results: Generated nanobubbles measured 50-100 nm in diameter and were stable over time. NBW exhibited intrinsic, time-dependent antibacterial effects that were independent of the solvent or dissolved gas itself. Antibacterial activity was more pronounced at lower bacterial loads and differed by gas type and bacterial species: N2-NBW was particularly effective against MRSA, whereas CO2-NBW and Air-NBW showed activity against ESBL-producing E. coli. Several NBW types demonstrated antibacterial effects against drug-resistant strains, although the magnitude and duration varied. Importantly, short-term exposure (≤60 min) did not reduce bacterial counts, indicating that measurable effects require prolonged immersion. Conclusion: NBW generated using relatively safe and inexpensive gases (excluding ozone, which is known to be cytotoxic) exerts reproducible antibacterial activity against diverse bacterial species, including resistant strains. However, its lack of rapid disinfectant action suggests that NBW is better suited for long-term immersion rather than short-contact disinfection. These findings support NBW as a potential safer and cost-effective strategy for immersion-based infection control and mitigation of antimicrobial resistance. |
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言語 |
en |
| 書誌情報 |
en : In Vivo
巻 40,
号 2,
p. 889-903,
発行日 2026-02-27
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| 出版者 |
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出版者 |
International Institute of Anticancer Research |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0258-851X |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.21873/invivo.14245 |
| 権利 |
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権利情報 |
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2026 The Author(s). Anticancer Research is published by the International Institute of Anticancer Research. |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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内容記述タイプ |
Other |
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内容記述 |
In Vivo, 40(2), pp.889-903; 2026 |
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言語 |
en |
IV40_889.pdf (3.8 MB)
