| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-04-07 |
| タイトル |
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タイトル |
Preoperative Gamma-Glutamyltransferase-to-Lymphocyte Ratio as an Independent Prognostic Biomarker in Patients Undergoing Radical Cystectomy for Bladder Cancer |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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主題Scheme |
UDC |
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主題URI |
bladder cancer |
| キーワード |
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言語 |
en |
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主題Scheme |
UDC |
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主題URI |
radical cystectomy |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題URI |
prognostic biomarker |
| キーワード |
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言語 |
en |
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主題URI |
gamma-glutamyltransferase-to-lymphocyte ratio |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Matsuo, Tomohiro
Mori, Shintaro
Honda, Hiroyuki
Kakita, Shota
Araki, Kyohei
Mitsunari, Kensuke
Ohba, Kojiro
Mochizuki, Yasushi
Imamura, Ryoichi
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background and Objectives: Gamma-glutamyltransferase-to-lymphocyte ratio (GLR) is a prognostic biomarker reflecting oxidative stress and host immune status. However, its prognostic value in patients with bladder cancer undergoing radical cystectomy (RC) remains unclear. This study aimed to investigate whether preoperative GLR predicts survival outcomes following RC. Materials and Methods: We retrospectively reviewed 110 patients with urothelial carcinoma of the bladder (pure urothelial carcinoma or urothelial carcinoma with variant histology) who underwent RC at a single tertiary center between 2008 and 2022. GLR was calculated as serum gamma-glutamyltransferase (U/L) divided by absolute lymphocyte count (×109/L) using routine preoperative blood samples. Patients were categorized into low-GLR (≤17.0; n = 54) and high-GLR (>17.0; n = 56) groups based on the cohort median cut-off (17.0). Overall survival (OS), recurrence-free survival (RFS), and cancer-specific survival (CSS) were assessed using Kaplan–Meier analysis and compared by log-rank tests. Cox proportional hazards models were used, including a preoperative model (Model 1) and a pathology-adjusted model incorporating postoperative variables (Model 2). Results: High GLR was associated with significantly worse OS, RFS, and CSS (log-rank: p = 0.020, p = 0.043, and p = 0.003, respectively). In multivariate analyses, high GLR was independently associated with inferior outcomes in both models. In Model 2, high GLR predicted worse OS (hazard ratio [HR] = 2.38; 95% confidence interval [CI] = 1.32–4.28; p = 0.003), RFS (HR = 2.37; 95% CI = 1.13–4.99; p = 0.020), and CSS (HR = 3.45; 95% CI = 1.56–8.52; p = 0.001). Conclusions: Preoperative GLR is a simple, inexpensive biomarker independently associated with survival after RC for bladder cancer, even after adjustment for established clinicopathological and pathological factors. GLR may support risk stratification and postoperative management, warranting prospective multicenter validation. |
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言語 |
en |
| 書誌情報 |
en : Medicina
巻 62,
号 2,
p. art. no. 343,
発行日 2026-02-08
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| 出版者 |
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出版者 |
MDPI |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1648-9144 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.3390/medicina62020343 |
| 権利 |
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権利情報 |
© 2026 by the authors. Published by MDPI on behalf of the Lithuanian University of Health Sciences. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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内容記述タイプ |
Other |
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内容記述 |
Medicina, 62(2), art. no. 343; 2026 |
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言語 |
en |
M62_343.pdf (453 KB)
