| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-04-07 |
| タイトル |
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タイトル |
A Randomised, Parallel-Group Study to Compare the Efficacy of 3% Phenothrin-Containing Jigger Lotion Versus Potassium Permanganate for Treatment of Tungiasis in Vihiga County, Kenya |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題URI |
tungiasis |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題URI |
randomised controlled trial |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題URI |
topical treatment |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題URI |
3% phenothrin lotion |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題URI |
potassium permanganate |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題URI |
resource-limited setting |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題URI |
Kenya |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Suzuki, Kana
Ongaya, Asiko
Amukoye, Evans
Kamiya, Yasuhiko
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Tungiasis, caused by the sand flea Tunga penetrans, results in itching and pain. Effective treatments, such as dimeticones, are often unaffordable. A 3% phenothrin lotion has shown safety and efficacy in Kenyan trials. This study compared the cure rate and safety of 3% phenothrin lotion (as the intervention) and 0.05% potassium permanganate (KMnO4; as the standard-care comparator) over 14 days. This parallel-group, three-arm, non-blinded, randomised comparative trial was conducted in Vihiga County, Kenya. Participants aged ≥2 years with ≥1 viable flea on each foot were allocated (2:1:1) to KMnO4, single-dose 3% phenothrin, or two-dose 3% phenothrin groups. Overall, 415 fleas from 79 participants were followed up to day 14 (KMnO4, 213; single-dose, 129; two-dose, 73). On days 4 and 7, the single-dose phenothrin showed significantly higher cure rates (11.6% and 21.7%) than KMnO4 (0.9% and 11.7%) (p < 0.001 and p = 0.013). The differences diminished by days 10 and 14 because of spontaneous flea death. The cure rate of the two-dose group on day-7 (8.2%) was lower than that of the single-dose group. Single-dose 3% phenothrin improved early cure rates compared to KMnO4, but not by days 10–14; two-dose phenothrin showed no benefit compared with single dose from day 7 onwards. |
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言語 |
en |
| 書誌情報 |
en : Tropical Medicine and Infectious Disease
巻 11,
号 2,
p. art. no. 47,
発行日 2026-02-09
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| 出版者 |
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出版者 |
MDPI |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2414-6366 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.3390/tropicalmed11020047 |
| 権利 |
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権利情報 |
© 2026 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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内容記述タイプ |
Other |
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内容記述 |
Tropical Medicine and Infectious Disease, 11(2), art. no. 47; 2026 |
|
言語 |
en |
TMIF11_47.pdf (788 KB)
