@article{oai:nagasaki-u.repo.nii.ac.jp:00020058,
 author = {Zea-Iriarte, Walter and Makiyama, Kazuya and Itsuno, Minoru and Umene, Yoshihiko and Hara, Kohei},
 issue = {4},
 journal = {Acta medica Nagasakiensia},
 month = {Dec},
 note = {Epidemiological data suggest an increase in both developed and undeveloped countries of inflammatory bowel disease. Furthermore, its etiology and pathophysiology remain unknown. Appropriated animal models are needed. We have studied a rat model of hapten-induced chronic colitis. In Wistar rats, intracolonic instillation of 20 mg or 42 mg of the hapten trinitrobenzene sulfonic acid in 30 % and 40 % ethanol proved to induce chronic colitis after 14 to 21 days of administration, in dose-dependent fashion when compared with ethanol alone that induced only acute colitis after three days of administration. This chronic colitis shares some characteristics with inflammatory bowel disease in humans, specially with Crohn's disease, such as transmural inflammation, development of strictures, ulcerations and infiltration of inflammatory cells throughout the colonic wall. These features make this model suitable for further studies of intestinal inflammation., Acta medica Nagasakiensia. 1994, 39(4), p.1-10},
 pages = {1--10},
 title = {Experimental-Induced Colitis in Rats by Ethanolic Solution of Trinitrobenzene Sulfonic Acid and Ethanol Alone : A Comparative Study},
 volume = {39},
 year = {1994}
}