{"created":"2023-05-15T16:44:23.281569+00:00","id":20074,"links":{},"metadata":{"_buckets":{"deposit":"be42d67c-943a-475f-87ef-c7d278f32e8f"},"_deposit":{"created_by":2,"id":"20074","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"20074"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00020074","sets":["29:30:1713167819629:1387"]},"author_link":["84583","84586","84584","84585"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994-12-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"100","bibliographicPageStart":"95","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Bronchiolitis obliterans organizing pneumonia (BOOP) is clinically and histologically difficult to differentiate from chronic eosinophilic pneumonia (CEP). The common histological feature of these diseases is an infiltration of mononuclear cells into the small airway, interstitial tissue and alveoli. Activation of T cells and secretion of lymphokines play a crucial role in the regulation and coordination of immune responses and inflammatory processes. In this study, we demonstrated the distribution of lymphocyte subpopulations and their stage of activation and T cellderived cytokine, IL-5 level in bronchoalveolar lavage (BAL) fluid obtained from patients with BOOP and CEP by comparison with sarcoidosis and diffuse panbronchiolitis (DPB). Flow cytometric analysis of T cell activation markers revealed that BOOP and sarcoidosis are characterized by increased absolute numbers of HLA-DR-bearing T cell subsets, while the relative numbers were increased in CEP and DPB. IL-5 in BAL fluids from BOOP and CEP was significantly high levels, and CEP patients with the high level of IL-5 showed the marked elevation of BAL eosinophils. Furthermor, it is of interest that the absolute numbers of HLA-DR T cells correlated with IL-5 levels in BAL fluid. These results suggest that activated T cells and secretion of IL-5 may be important factors in the pathogenetic processes of BOOP and CEP.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia. 1994, 39(4), p.95-100","subitem_description_type":"Other"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"P00095-P00100"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sawa, Hideaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kadota, Jun-Ichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kohno, Shigeru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Abe, Koh"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"acta39_04_17_t.pdf","filesize":[{"value":"660.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"acta39_04_17_t.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/20074/files/acta39_04_17_t.pdf"},"version_id":"dcb99c5d-feac-40b1-b7cd-45c7ea972b23"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"BOOP","subitem_subject_scheme":"Other"},{"subitem_subject":"Chronic eosinophilic pneumonia","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-5","subitem_subject_scheme":"Other"},{"subitem_subject":"Activated T cells","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Interleukin 5 Levels in Bronchoalveolar Lavage Fluid from Patients with Interstitial Lung Disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Interleukin 5 Levels in Bronchoalveolar Lavage Fluid from Patients with Interstitial Lung Disease"}]},"item_type_id":"3","owner":"2","path":["1387"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-03-13"},"publish_date":"2008-03-13","publish_status":"0","recid":"20074","relation_version_is_last":true,"title":["Interleukin 5 Levels in Bronchoalveolar Lavage Fluid from Patients with Interstitial Lung Disease"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2024-04-17T04:07:08.675732+00:00"}