{"created":"2023-05-15T16:44:27.864111+00:00","id":20156,"links":{},"metadata":{"_buckets":{"deposit":"4312cd6f-119e-42d2-ad2f-61fbb6b9105b"},"_deposit":{"created_by":2,"id":"20156","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"20156"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00020156","sets":["29:30:1713167819629:1393"]},"author_link":["85014","85016","85010","85013","85015","85012","85011"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998-06-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"37","bibliographicPageStart":"33","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We applied PCR strategies to detect the common types of ﾎｱ- thalassemia determinants which were associated with ﾎｲ- thalassemia in northern Thailand. Two types of deletions in the ﾎｱ-globin gene locus;the 18 kb deletion of Southeast Asian type(-ﾎｱSEA)and the 3.7 kb rightward deletion(-ﾎｱ3.7), and the most prevalent non-deletion mutation, Hb Constant Spring(ﾎｱC8, TAA to CAA at the codon 141)were investigated in 22 cases of ﾎｲ-thalassemia. Nine ﾎｲ-thalassemia patients were found to be associated with one or two of these defective ﾎｱ-globin gene determinants and the mean hemoglobin concentration in these patients was 6.3 ﾂｱ 1.1 g/dl whereas it was 5.6ﾂｱ.0.8 g/dl in 12 ﾎｲ-thalassemia patients without ﾎｱ- globin gene abnormalities ; the difference is statistically insignificant (p = 0.08). The level of anemia was severe in the ﾎｲ-thalassemia patients carrying a single ﾎｱ-globin gene abnormality in the heterozygous compounds ; whereas the (ﾎｲ-thalassemias withﾎｱ-globin gene defects in both alleles showed less severe anemia. A patient carrying the ﾎｱ ・｣8 determinant in homozygous compound showed the highest hemoglobin level among these ﾎｲ-thalassemia patients.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia. 1998, 43(1-2), p.33-37","subitem_description_type":"Other"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"P00033-P00037"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kudeken, Mika"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Asato, Tsuyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuda, Satoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakashima, Yasutsugu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takei, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Buasaengchan, Suwanna"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Makonkawkeyoon, Luksana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"acta43_01_06_t.pdf","filesize":[{"value":"671.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"acta43_01_06_t.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/20156/files/acta43_01_06_t.pdf"},"version_id":"84cc7a5a-905b-4e45-b3ed-afd475d1ad00"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"a -thalassemia","subitem_subject_scheme":"Other"},{"subitem_subject":"R -thalassemia","subitem_subject_scheme":"Other"},{"subitem_subject":"polymerase chain reaction","subitem_subject_scheme":"Other"},{"subitem_subject":"anemia","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Molecular Analysis of Common Types ofﾎｱ-Thalassemia Associated with(ﾎｲ-Thalassemia in Northern Thailand","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Molecular Analysis of Common Types ofﾎｱ-Thalassemia Associated with(ﾎｲ-Thalassemia in Northern Thailand"}]},"item_type_id":"3","owner":"2","path":["1393"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-03-13"},"publish_date":"2008-03-13","publish_status":"0","recid":"20156","relation_version_is_last":true,"title":["Molecular Analysis of Common Types ofﾎｱ-Thalassemia Associated with(ﾎｲ-Thalassemia in Northern Thailand"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2024-04-17T04:05:19.598284+00:00"}